106516-04-5 Usage
Heterocyclic compound
Indole ring and pyridine moiety The compound contains both an indole ring (a benzene ring with a pyrrole attached) and a pyridine moiety (a six-membered nitrogen-containing ring) in its structure.
Fluorophenyl group
4-fluorophenyl The compound has a fluorophenyl group (a benzene ring with a fluorine atom at the 4-position) attached to the indole ring.
Tetrahydro-1-methyl-4-pyridinyl group
1,2,3,6-tetrahydro-1-methyl-4-pyridinyl The compound also has a 1,2,3,6-tetrahydro-1-methyl-4-pyridinyl group (a pyridine ring with a methyl group and four hydrogen atoms in a tetrahydro environment) attached to the indole ring, adding complexity to its structure.
Pharmaceutical research and drug development potential
Unique structural features and biological activities The compound has potential applications in pharmaceutical research and drug development due to its unique structural features and potential biological activities.
Medicinal chemistry interest
Indole and pyridine moieties The presence of both an indole and a pyridine moiety in its structure makes it an interesting candidate for further investigation in medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 106516-04-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,5,1 and 6 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 106516-04:
(8*1)+(7*0)+(6*6)+(5*5)+(4*1)+(3*6)+(2*0)+(1*4)=95
95 % 10 = 5
So 106516-04-5 is a valid CAS Registry Number.
106516-04-5Relevant academic research and scientific papers
Noncataleptogenic, centrally acting dopamine D-2 and serotonin 5-HT2 antagonists within a series of 3-substituted 1-(4-fluorophenyl)-1H-indoles
Perregaard,Arnt,Bogeso,Hyttel,Sanchez
, p. 1092 - 1101 (2007/10/02)
A series of 1-(4-fluorophenyl)-1H-indoles substituted at the 3-position with 1-piperazinyl, 1,2,3,6-tetrahydro-4-pyridinyl, and 4-piperidinyl was synthesized. Within all three subseries potent dopamine D-2 and serotonin 5- HT2 receptor affinity was found in ligand binding studies. Quipazine-induced head twitches in rats were inhibited by most derivatives as a measure of central 5-HT2 receptor antagonism. Piperazinyl and tetrahydropyridyl indoles were cataleptogenic, while piperidyl substituted indoles surprisingly were found to be noncataleptogenic or only weakly cataleptogenic. Noncataleptogenic piperidyl derivatives also failed to block dopaminergic- mediated stereotypies, that is methyl phenidate-induced gnawing behavior in mice. These profiles resemble that of the atypical neuroleptic clozapine. 1- Ethyl-2-imidazolidinone was found to be the optimal substituent of the basic nitrogen atom in order to avoid catalepsy. The atypical neuroleptic 1-[2-[4- [5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]-1-piperidinyl]ethyl]-2- imidazolidinone (sertindole, compound 14c) was selected for further development as a result of these structure/activity studies.
