106517-64-0

Basic information

• Product Name: 5,6-METHYLENEDIOXYINDOLE-3-CARBOXYLIC ACID
• Synonyms: 5,6-METHYLENEDIOXYINDOLE-3-CARBOXYLIC ACID;5,6-Methylenedioxy-2-indole carboxylic acid;5H-[1,3]Dioxolo[4,5-f]indole-6-carboxylic acid
• CAS NO: 106517-64-0
• Molecular Formula: C₁₀H₇NO₄
• Molecular Weight: 205.17
• Mol File: 106517-64-0.mol

Chemical Properties

• Melting Point: 250-251 °C (decomp)
• Boiling Point: 492.8±40.0 °C(Predicted)
• Appearance: /
• Density: 1.633±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.48±0.20(Predicted)
• CAS DataBase Reference: 5,6-METHYLENEDIOXYINDOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-METHYLENEDIOXYINDOLE-3-CARBOXYLIC ACID(106517-64-0)
• EPA Substance Registry System: 5,6-METHYLENEDIOXYINDOLE-3-CARBOXYLIC ACID(106517-64-0)

Safety Data

• Hazardous Substances Data: 106517-64-0(Hazardous Substances Data)

Usage

Uses

Used in Biochemical Research:
5,6-Methylenedioxyindole-3-carboxylic acid is used as a research compound for studying its bioactivities and potential applications in various fields. Its unique structure and properties make it a promising candidate for further investigation.
Used in Pharmaceutical Industry:
5,6-Methylenedioxyindole-3-carboxylic acid is used as a starting material or intermediate in the synthesis of various pharmaceutical compounds. Its indole-based structure and functional groups may contribute to the development of new drugs with potential therapeutic applications.
Used in Drug Development:
5,6-Methylenedioxyindole-3-carboxylic acid is used as a lead compound in drug discovery and development. Its potential bioactivities and interactions with biological targets may lead to the identification of new therapeutic agents for various diseases and conditions.
Used in Chemical Synthesis:
5,6-Methylenedioxyindole-3-carboxylic acid is used as a building block in the synthesis of more complex molecules and compounds. Its versatile structure and functional groups make it a valuable component in the creation of novel chemical entities with potential applications in various industries.

Upstream product

• 94527-32-9 5H-1,3-dioxolo[4,5-f]indole-6-carboxylic acid ethyl ester 
• 136818-52-5 5H-[1,3]dioxolo[4,5-f]indole-6-carboxylic acid methyl ester 
• 120-57-0 piperonal 
• 160857-78-3 (Z)-2-azido-3-(1,3-benzodioxol-5-yl)acrylic acid methyl ester 
• 24536-45-6 (Z)-Ethyl 2-azido-3-(benzo[d][1,3]dioxol-5-yl)acrylate 
• 1000802-34-5 6-iodobenzo[d][1,3]dioxol-5-amine 
• 127-17-3 2-oxo-propionic acid 

Downstream Products

• 690639-08-8 N-(3,4-dihydroxyphenethyl)-5,6-dihydroxy-1H-indole-2-carboxamide 

Relevant articles and documents

Indoles and pyridazinoindoles as nonnucleoside analog inhibitors of HIV-1 reverse transcriptase

The synthesis and the study of the activity of new indol-2-carboxamides and pyridazinoindoles as inhibitors of HIV-1 reverse transcriptase (RT) are presented.The activity of the compounds synthesized as inhibitors of different types of HIV-1 RT (wild type enzyme and mutant forms P236L, Y181C and P236L/Y181C) was evaluated.The activity of the most active compounds was investigated in the syncytia reduction in vitro assay, in HIV-1IIIB-infected HT4lacZ-1 cells.Their potential cytotoxicity was determined in parallel.Two lead compounds,N-piperazin>-5,6-methylenedioxy indol-2-carboxamide 7q and N-piperazin>-5,6-methylenedioxyindol-2-carboxamide 7s have been identified. - Keywords: indole; nonnucleoside RT inhibitor; syncytia assay; HIV-1IIIBHT4lacZ-1 cells

Flexibility of small molecular CD4 mimics as HIV entry inhibitors

CD4 mimics such as YIR-821 and its derivatives are small molecules which inhibit the interaction between the Phe43 cavity of HIV-1 gp120 with host CD4, an interaction that is involved in the entry of HIV to cells. Known CD4 mimics generally possess three

INDOLE CARBOXAMIDE DERIVATIVES AND USES THEREOF

A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein.

Hyperbranched molecular structures with potential antiviral activity: Derivatives of 5,6-dihydroxyindole-2-carboxylic acid

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requi

CBI analogues of the duocarmycins and CC-1065

An extensive series of CBI analogues of the duocarmycins and CC-1065 exploring substituent effects within the first indole DNA binding subunit is detailed. In general, substitution at the indole C5 position led to cytotoxic potency enhancements that can be ≧1000-fold providing simplified analogues containing a single DNA binding subunit that are more potent (IC50=2-3 pM) than CBI-TMI, duocarmycin SA, or CC-1065. The increases in cytotoxicity correlate well with accompanying increases in the rate and efficiency of DNA alkylation. This effect is more pronounced with the CBI versus DSA or CPI based analogues. Moreover, this effect is largely insensitive to the electronic character of the C5 substituent but is sensitive to the size, rigid length, and shape (sp, sp2, sp3 hybridization) of this substituent consistent with expectation that the impact is due simply to its presence.

Anti-aids piperazines

The present invention includes diaromatic substituted heterocyclic compounds (III) STR1 which are useful in treating individuals infected with the HIV virus. The invention includes certain previously generically disclosed anti-AIDS piperazinyl compounds (V) and a method of treating HIV infected individuals with the indoles of formula (V) and the anti-AIDS amines (X).