1065181-58-9

Usage

Uses

Used in Organic Synthesis:
Ethyl 5-bromo-1H-indole-7-carboxylate is used as a building block in organic synthesis for the creation of diverse chemical compounds. Its structure and reactivity make it a versatile intermediate, facilitating the production of a wide range of molecules.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, Ethyl 5-bromo-1H-indole-7-carboxylate is utilized as a key intermediate for the synthesis of pharmaceuticals. Its presence in the indole ring suggests potential bioactivity, which is of interest for drug discovery and development, as it may contribute to the creation of new therapeutic agents.
Used in Drug Discovery and Development:
Ethyl 5-bromo-1H-indole-7-carboxylate is employed as a target for research in drug discovery and development due to its potential pharmacological properties. Ethyl 5-broMo-1H-indole-7-carboxylate's structure and functional groups make it a promising candidate for the exploration of new therapeutic applications and the advancement of existing treatments.

Upstream product

• 1065181-52-3 1-(1,1-dimethylethyl) 7-ethyl 2,3-dihydro-1H-indole-1,7-dicarboxylate 
• 1065181-56-7 ethyl 5-bromo-2,3-dihydro-1H-indole-7-carboxylate 
• 143262-10-6 1-(tert-butoxycarbonyl)indoline 
• 496-15-1 1-indoline 

Downstream Products

• 1065175-72-5 3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-phenyl-1H-indole-7-carboxamide 
• 1065179-21-6 3-(1,1-dioxidotetrahydro-3-thienyl)-5-(4-fluorophenyl)-1H-indole-7-carboxamide 
• 860624-96-0 methyl 5-phenyl-1H-indole-7-carboxylate 
• 881374-64-7 5-phenyl-1H-indole-7-carboxylic acid 
• 881380-98-9 3-[1-(ethenylsulfonyl)-4-piperidinyl]-5-phenyl-1H-indole-7-carboxamide 

Relevant academic research and scientific papers

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent

IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for oral activity. In doing so

INDOLE CARBOXAMIDES AS IKK2 INHIBITORS

The invention is directed to novel indole carboxamide compounds. Specifically, the invention is directed to compounds according to formula (I): wherein R1, R2, R3, R4, and m are as defined herein. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, rhinitis, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.