1065181-58-9 Usage
General Description
Ethyl 5-bromo-1H-indole-7-carboxylate is a chemical compound with the molecular formula C12H10BrNO2. It is a derivative of the indole family and contains a bromo group as well as an ethyl ester functional group. Ethyl 5-broMo-1H-indole-7-carboxylate is commonly used in organic synthesis and medicinal chemistry, as it can serve as a building block for the synthesis of various pharmaceuticals and bioactive molecules. Its structure and reactivity make it a useful intermediate in the production of diverse chemical compounds. Additionally, the presence of the indole ring in the structure of ethyl 5-bromo-1H-indole-7-carboxylate suggests potential bioactivity and pharmacological properties, making it an interesting target for further research in drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 1065181-58-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,5,1,8 and 1 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1065181-58:
(9*1)+(8*0)+(7*6)+(6*5)+(5*1)+(4*8)+(3*1)+(2*5)+(1*8)=139
139 % 10 = 9
So 1065181-58-9 is a valid CAS Registry Number.
1065181-58-9Relevant articles and documents
3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent
Kerns, Jeffrey K.,Busch-Petersen, Jakob,Fu, Wei,Boehm, Jeffrey C.,Nie, Hong,Muratore, Michael,Bullion, Ann,Lin, Guoliang,Li, Huijie,Davis, Roderick,Lin, Xichen,Lakdawala, Ami S.,Cousins, Rick,Field, Rita,Payne, Jeremy,Miller, David D.,Bamborough, Paul,Christopher, John A.,Baldwin, Ian,Osborn, Ruth R.,Yonchuk, John,Webb, Edward,Rumsey, William L.
, p. 1164 - 1169 (2018/11/23)
IκB kinase β (IKKβ or IKK2) is a key regulator of nuclear factor kappa B (NF-κB) and has received attention as a therapeutic target. Herein we report on the optimization of a series of 3,5-disubstituted-indole-7-carboxamides for oral activity. In doing so
