1065194-74-2Relevant academic research and scientific papers
Rhodium-catalyzed asymmetric transfer hydrogenation of aryl alkyl ketones employing ligands derived from amino acids
Wettergren, Jenny,Zaitsev, Alexey B.,Adolfsson, Hans
, p. 2556 - 2562 (2007)
The combination of (pentamethylcyclopentadienyl)rhodium dichloride dimer [{RhCl2Cp*}2] and pseudodipeptide ligands, formed from N-Boc protected amino acids and amino alcohols, resulted in efficient and selective catalysts for the asymmetric transfer hydrogenation of ketones in 2-propanol. A number of different secondary alcohols was obtained in high yields and in excellent enantioselectivity using these in situ formed catalysts. Deuterium-labeling experiments showed that the hydride transfer reaction occurs via the monohydridic route.
