106521-82-8Relevant articles and documents
Synthesis and Biological Activity of Novel Calcium Channel Blockers: 2,5-Dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic Acid Esters and 2,5-Dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic Acid Esters
Atwal, Karnail S.,Bergey, James L.,Hedberg, Anders,Moreland, Suzanne
, p. 635 - 640 (2007/10/02)
2,5-Dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters, based on the structures of dihydropyridines and diltiazem, were synthesized from o-aminothiophenol and 2-(phenylmethylene)-3-oxobutanoic acid esters.Biological evaluation in the p
Antihypertensive 1,5-benzothiazepine derivatives, compositions, and method of use therefor
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, (2008/06/13)
Compounds of formula STR1 wherein X is S or SO2, R4 is aryl or hetero, and R1 is hydrogen or STR2 are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents.