106521-87-3

Upstream product

• 20048-02-6 methyl (E)-2-(4-methoxybenzylidene)-3-oxobutanoate 
• 137-07-5 2-amino-benzenethiol 
• 20048-01-5 methyl (Z)-2-(4-methoxybenzylidene)-3-oxobutanoate 

Relevant academic research and scientific papers

Antihypertensive 1,5-benzothiazepine derivatives, compositions, and method of use therefor

Compounds of formula STR1 wherein X is S or SO2, R4 is aryl or hetero, and R1 is hydrogen or STR2 are disclosed. These compounds are useful as cardiovascular agents and especially as anti-hypertensive agents.

Synthesis and Biological Activity of Novel Calcium Channel Blockers: 2,5-Dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic Acid Esters and 2,5-Dihydro-4-methyl-2-phenyl-1,5-benzodiazepine-3-carboxylic Acid Esters

2,5-Dihydro-4-methyl-2-phenyl-1,5-benzothiazepine-3-carboxylic acid esters, based on the structures of dihydropyridines and diltiazem, were synthesized from o-aminothiophenol and 2-(phenylmethylene)-3-oxobutanoic acid esters.Biological evaluation in the p