1065269-88-6Relevant articles and documents
Enantioselective polyene cyclization via organo-SOMO catalysis
Rendler, Sebastian,MacMillan, David W.C.
supporting information; experimental part, p. 5027 - 5029 (2010/06/14)
The first organocatalytic enantioselective radical polycyclization has been accomplished using singly occupied molecular orbital (SOMO) catalysis. The presented strategy relies on a selective single-electron oxidation of chiral enamines formed by condensation of polyenals with an imidazolidinone catalyst employing a suitable copper(II) oxidant. The reaction proceeds under mildly acidic conditions at room temperature and shows compatibility with an array of electron-poor as well as electron-rich functional groups. Upon termination by radical arylation followed by subsequent oxidation and rearomatization, a range of polycyclic aldehydes were accessed (12 examples, 54?77% yield, 85?93% ee). The enantioselective formation of up to six new carbocycles in a single catalyst-controlled cascade is described. Evidence for a radical-based cascade mechanism is indicated by a series of experimental results.
SUBSTITUTED DIBENZOIC ACID DERIVATIVES AND USE THEREOF
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Page/Page column 13, (2010/07/08)
The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention