1065273-72-4Relevant academic research and scientific papers
4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV
Kaelin, David E.,Smenton, Abigail L.,Eiermann, George J.,He, Huaibing,Leiting, Barbara,Lyons, Kathryn A.,Patel, Reshma A.,Patel, Sangita B.,Petrov, Alexsandr,Scapin, Giovanna,Wu, Joseph K.,Thornberry, Nancy A.,Weber, Ann E.,Duffy, Joseph L.
, p. 5806 - 5811 (2008/03/14)
A novel series of 4-arylcyclohexylalanine DPP-4 inhibitors was synthesized and tested for inhibitory activity as well as selectivity over the related proline-specific enzymes DPP-8 and DPP-9. Optimization of this series led to 28 (DPP-4 IC50 =
