1065488-21-2

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 768-60-5 4-methoxyphenylacetylen 
• 176910-67-1 2-(4-methoxyphenylethynyl)benzaldehyde 

Downstream Products

• 1095128-49-6 C₂₂H₁₈BrNO₆ 
• 1065488-39-2 C₁₆H₁₂INO₂ 
• 1140903-34-9 C₁₆H₁₂BrNO₂ 
• 1127562-20-2 3-(4-methoxyphenyl)isoquinoline 2-oxide 
• 1401453-07-3 3-(4-methoxyphenyl)-1-m-tolylisoquinoline 2-oxide 
• 1401453-08-4 3-(4-methoxyphenyl)-1-(3-nitrophenyl)isoquinoline 2-oxide 
• 1401453-09-5 3-(4-methoxyphenyl)-1-(phenanthren-9-yl)isoquinoline 2-oxide 
• 1437780-74-9 1-(4-(tert-butyl)phenoxy)-3-(4-methoxyphenyl)isoquinoline 
• 1589566-18-6 (Z)-1-(1-(3-benzylidene-1,3-dihydroisobenzofuran-1-yl)cyclopropyl)-3-(4-methoxyphenyl)isoquinoline 
• 1459141-16-2 1-(4-iodo-3-(4-methoxyphenyl)isoquinolin-1-yl)-1,3-di-p-tolylurea 
• 1583251-58-4 3-(4-methoxyphenyl)-1-[(trifluoromethyl)thio]isoquinoline 

Relevant academic research and scientific papers

Synthesis of 2-(Isoquinolin-1-yl)prop-2-en-1-ones via Silver(I)-Catalyzed One-Pot Tandem Reaction of ortho-Alkynylbenzaldoximes with Propargylic Alcohols

The silver(I)-catalyzed reaction of ortho-alkynylbenzaldoximes with propargylic alcohols represents a new strategy for the divergent one-pot synthesis of 2-(isoquinolin-1-yl) prop-2-en-1-ones via tandem 6-endo-cyclization, 1,3-dipolar cycloaddition, and intramolecular dehydrative opening of the 2,3-dihydroisoxazole ring. This synthetic protocol tolerates a wide variety of ortho-alkynylbenzaldoximes and propargylic alcohols and affords the corresponding products in excellent yields.

A metal-free tandem dehydrogenative α-arylation reaction of propargylic alcohols with 2-alkynylbenzaldoximes toward the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenone skeletons

A tandem reaction of 2-alkynylbenzaldoximes with propargylic alcohols has been developed for the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenones. Employing 2-alkynylbenzaldoximes as a precursor in the presence of Br2 generates 4-bromo-isoquinoline-N-

Synthesis of N-(isoquinolin-1-yl)sulfonamides via Ag2O-catalyzed tandem reaction of ortho-alkynylbenzaldoximes with benchtop stabilized ketenimines

In this project, a moderately efficient approach to multisubstituted N-(isoquinolin-1-yl)sulfonamide derivatives was illustrated, utilizing ortho-alkynylbenzaldoximes and zwitterionic ketenimine salts in a tandem reaction catalyzed by silver oxide. The oxophilicity of Ag2O, along with its nature as Lewis acid, pave the way for a smooth [3 + 2] cycloaddition between isoquinoline N-oxides and ketenimine species, which is a key step in this reaction. DFT calculation suggests that 1,3-dipolar cycloaddition of nitrone and ketenimine proceeds through a selective stepwise mechanism.

Palladium-catalyzed C-H oxidation of isoquinoline N-oxides: Selective alkylation with dialkyl sulfoxides and halogenation with dihalo sulfoxides

A novel palladium-catalyzed C-H oxidation of isoquinoline N-oxides has been developed for regioselectively synthesizing substituted isoquinolines. The method represents the first example of using dialkyl sulfoxides as the alkyl sources for the construction of 1-alkylated isoquinolines. Moreover, the regioselective halogenation of isoquinoline N-oxides is also successful using dihalo sulfoxides as the halide sources. Copyright