1065488-55-2Relevant academic research and scientific papers
Access to functionalized isoquinoline N-oxides via sequential electrophilic cyclization/cross-coupling reactions
Ding, Qiuping,Wu, Jie
supporting information; experimental part, p. 1850 - 1854 (2009/07/24)
Electrophilic cyclization of 2-alkynylbenzaldoximes with various electrophiles leads to the formation of 4-iodoisoquinoline N-oxides or 4-bromo-isoquinoline N-oxides under mild conditions. The reaction can be transferred to highly functionalized isoquinol
Iodine-mediated electrophilic cyclization of 2-alkynylbenzaldoximes leading to the formation of iodoisoquinoline N-oxides
Huo, Zhibao,Tomeba, Hisamitsu,Yamamoto, Yoshinori
, p. 5531 - 5533 (2008/12/22)
Reaction of 2-alkynylbenzaldoximes 1 with 5 equiv of iodine in EtOH at room temperature gives the corresponding iodoisoquinoline N-oxides 2 in good to excellent yields. The cyclization proceeds very smoothly and quickly without any additives such as bases
