106560-14-9 Usage
Description
Farom was launched in Japan for use as an antibiotic against common
respiratory tract pathogens. It can be prepared by several related routes of about
seven steps starting with tetrahydrofuran-2-thiocarboxylic acid and a silylated
azetidinone. It is a broad spectrum oral penem antibiotic that is β-lactamase stable.
Farom is the most active β-lactam against anaerobes (more than cefaclor, cefixime
and amoxicillin) but also has activity against Gram-positive, Gram-negative and
enterobacteriaceae. It is equally active against strains carrying plasmid and
chromosome mediated β-lactamases. The short plasma elimination half-life is the
result of hydrolysis by renal dehydropeptidase. It is more stable to hydrolysis by
extended spectrum β-lactamases than some second and third generation
cephalosporins.
Originator
Suntory (Japan)
Uses
Different sources of media describe the Uses of 106560-14-9 differently. You can refer to the following data:
1. Faropenem (cas# 106560-14-9) is a compound useful in organic synthesis.
2. Treatmentof bacterial infections.
Brand name
Farom
Antimicrobial activity
An orally active penem with a broad spectrum of antibacterial
activity, including activity against selected anaerobic
pathogens. Although it is active against most enterobacteria, it has reduced activity against Ser. marcescens,
Enterobacter spp. and some Providencia spp. It generally
retains activity against many Gram-positive organisms,
but has no useful activity against Ps. aeruginosa. It has
reduced activity against E. faecium, methicillin-resistant
Staph. aureus (MRSA) and some strains of coagulase-negative
staphylococci. It is stable to hydrolysis by extended
spectrum β-lactamases, but is hydrolyzed by carbapenemases.
Esterified prodrugs with increased bioavailability
have been studied in clinical trials but have not received
regulatory approval.
Check Digit Verification of cas no
The CAS Registry Mumber 106560-14-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,5,6 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 106560-14:
(8*1)+(7*0)+(6*6)+(5*5)+(4*6)+(3*0)+(2*1)+(1*4)=99
99 % 10 = 9
So 106560-14-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H15NO5S/c1-5(14)7-10(15)13-8(12(16)17)9(19-11(7)13)6-3-2-4-18-6/h5-7,11,14H,2-4H2,1H3,(H,16,17)/t5-,6-,7+,11-/m1/s1
106560-14-9Relevant articles and documents
A synthesis method of faropenem sodium
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Paragraph 0015; 0036; 0037, (2017/07/14)
The invention provides a method for synthesizing faropenem sodium. According to the method, oxalic acid chloride p-nitrobenzyl ester is used for replacing allyloxy oxalyl chloride in a conventional process, and thus the generation of polymer impurities is effectively prevented, and the raw material conversion rate and the product yield are increased; by adopting a method of catalytic hydrogenation under an acidic condition, silylation protection groups and p-nitrobenzyl ester protection groups are removed, organophosphorus impurities which are difficult to treat are effectively prevented, the separation and purification of products are facilitated, the maneuverability is improved, and the industrialized production is facilitated.
SOUP FAROPENEM FREE ACID
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Page/Page column 7-8, (2008/06/13)
The present invention provides solid form of faropenem free acid, its hydrates and processes for their preparation thereof. Thus, for example, dissolving an alkali metal salt of faropenem in water, adjusting the pH of the solution formed with an acid to below about 2.5 and collecting the precipitated solid to obtain solid faropenem free acid.
