1065608-51-6

Basic information

• Product Name: 1-Boc-azepane-4-Methanol
• Synonyms: 1-Boc-azepane-4-Methanol;tert-butyl 4-(hydroxymethyl)azepane-1-carboxylate;4-Hydroxymethyl-Azepane-1-Carboxylic Acid Tert-Butyl Ester
• CAS NO: 1065608-51-6
• Molecular Formula: C₁₂H₂₃NO₃
• Molecular Weight: 229.31592
• Mol File: 1065608-51-6.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Boc-azepane-4-Methanol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-azepane-4-Methanol(1065608-51-6)
• EPA Substance Registry System: 1-Boc-azepane-4-Methanol(1065608-51-6)

Safety Data

• Hazardous Substances Data: 1065608-51-6(Hazardous Substances Data)

Usage

General Description

1-Boc-azepane-4-Methanol, also known as 4-hydroxy-1-[(1-methylethoxy)carbonyl]azepane, is a chemical compound with the molecular formula C12H23NO3. It is a derivative of azepane and contains a 4-methylmorpholine structure. 1-Boc-azepane-4-Methanol is commonly used as a building block in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. Its hydroxyl group allows for chemical modification and functionalization, making it a versatile intermediate in the synthesis of various organic compounds. Additionally, 1-Boc-azepane-4-Methanol is also used as a chiral auxiliary in asymmetric synthesis, providing a useful tool for the preparation of enantiomerically pure compounds.

Upstream product

• 1259065-07-0 1-tert-butyl 4-methyl azepane-1,4-dicarboxylate 
• 50-00-0 formaldehyd 
• 912444-90-7 1-(tertbutyl) 4-ethyl 2,3,6,7-tetrahydro-1H-azepine-1,4-dicarboxylate 

Downstream Products

• 1369353-14-9 tert-butyl 4-(aminomethyl)azepane-1-carboxylate 

Relevant articles and documents

Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon

Radical hydroxymethylation using formaldehyde as a C1 synthon is challenging due to the reversible and endothermic nature of the addition process. Here we report a strategy that couples alkyl iodide building blocks with formaldehyde through the use of photocatalysis and a phosphine additive. Halogen-atom transfer (XAT) from α-aminoalkyl radicals is leveraged to convert the iodide into the corresponding open-shell species, while its following addition to formaldehyde is rendered irreversible by trapping the transient O-radical with PPh3. This event delivers a phosphoranyl radical that re-generates the alkyl radical and provides the hydroxymethylated product.

PYRAZOLOPYRIDINE PYRAZOLOPYRIMIDINE AND RELATED COMPOUNDS

In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.