1065628-75-2

Upstream product

• 2550-26-7 4-Phenyl-2-butanone 

Downstream Products

• 1094165-48-6 C₂₀H₂₆O₄ 
• 1186514-16-8 2-acetyldioxy-2-hydroperoxy-4-phenylbutane 

Relevant academic research and scientific papers

Phosphomolybdic acid catalyzed synthesis of 1,2,4,5-tetraoxanes

1,1-Dihydroperoxides were converted into 1,2,4,5-tetraoxanes through condensation with the corresponding ketones in 36-91% yields using phosphomolybdic acid as the catalyst and anhydrous MgSO4 as the water scavenger. Georg Thieme Verlag Stuttgart · New York.

Generation of singlet oxygen from fragmentation of monoactivated 1,1-dihydroperoxides

The first singlet excited state of molecular oxygen (1O 2) is an important oxidant in chemistry, biology, and medicine. 1O2 is most often generated through photosensitized excitation of ground-state oxygen. 1O2 can also be generated chemically through the decomposition of hydrogen peroxide and other peroxides. However, most of these "dark oxygenations" require water-rich media associated with short 1O2 lifetimes, and there is a need for oxygenations able to be conducted in organic solvents. We now report that monoactivated derivatives of 1,1-dihydroperoxides undergo a previously unobserved fragmentation to generate high yields of singlet molecular oxygen (1O2). The fragmentations, which can be conducted in a variety of organic solvents, require a geminal relationship between a peroxyanion and a peroxide activated toward heterolytic cleavage. The reaction is general for a range of skeletal frameworks and activating groups and, via in situ activation, can be applied directly to 1,1-dihydroperoxides. Our investigation suggests the fragmentation involves rate-limiting formation of a peroxyanion that decomposes via a Grob-like process.

Mild and efficient Re(VII)-catalyzed synthesis of 1,1-dihydroperoxides

(Chemical Equation Presented) Re2O7 in CH 3CN is a remarkably efficient and mild catalyst for the peroxyacetalization of ketones, aldehydes, or acetals by H2O 2 to generate 1,1-dihydroperoxides. Me3SiOReO3 and methyl rhenium trioxide (MTO) are also effective catalysts under these reaction conditions.

Synthesis of 1,2-dioxolanes by annulation reactions of peroxycarbenium ions with alkenes

(Chemical Equation Presented) The annulation reactions of alkenes with peroxycarbenium ions enable the synthesis of a variety of functionalizable 1,2-dioxolanes. Triethysilyl-protected peroxycarbenium ions proved to be optimal for the annulation reaction. Using this method, plakinic acid analogues can be synthesized in three steps from the corresponding ketone and alkene.