106590-35-6Relevant academic research and scientific papers
Design of mechanism-based inhibitors of transthyretin amyloidosis: Studies with biphenyl ethers and new structural templates
Gupta, Sarika,Chhibber, Manmohan,Sinha, Sharmistha,Surolia, Avadhesha
, p. 5589 - 5599 (2008/03/17)
Transthyretin (TTR), a tetrameric thyroxine (T4) carrier protein, is associated with a variety of amyloid diseases. In this study, we explore the potential of biphenyl ethers (BPE), which are shown to interact with a high affinity to its T4 binding site t
Novel diphenyl ethers: Design, docking studies, synthesis and inhibition of enoyl ACP reductase of Plasmodium falciparum and Escherichia coli
Chhibber, Manmohan,Kumar, Gyanendra,Parasuraman, Prasanna,Ramya,Surolia, Namita,Surolia, Avadhesha
, p. 8086 - 8098 (2007/10/03)
We designed some novel diphenyl ethers and determined their binding energies for Enoyl-Acyl Carrier Protein Reductase (ENR) of Plasmodium falciparum using Autodock. Out of these, we synthesized the promising compounds and tested them for their inhibitory
