106593-58-2Relevant academic research and scientific papers
Method for preparing 8 -methyldialdehyde
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Paragraph 0044; 0050-0051; 0054; 0060-0061; 0064; 0070-0071, (2021/11/03)
To the preparation method of 8 - chloro 6 - hexanol, the hydroxyl is firstly protected with the dihydropyran under the catalysis of p-toluenesulfonic acid, and -1 -chloro 6 -hexyl tetrahydropyranyl is obtained. 6 -chloro -hexyl tetrahydropyranyl ether is reacted with magnesium chips to form a formative reagent and reacted with 1 - bromo -2 - methyl - butane under the catalysis of cuprous bromide to obtain the intermediate 8 - methyl -tetrahydropyran ether. The intermediates do not need to be purified, and the hydroxyl group is removed directly under acidic conditions to obtain 8 - methyl -1 - sunflower. Finally, 2, 2, 6 and 6 - tetramethylpiperidine are oxidized to obtain the product 8 - methyldialdehyde. The synthesis process uses common reagents, is low in cost, mild in reaction conditions and high in yield, is suitable for large-scale industrial production, and has a good application prospect in the field of food additives.
Synthesis of Optically Active Aggregation Pheromone Analogues of the Red Flour Beetle, Tribolium castaneum
Suzuki, Takahisa,Ozaki, Jotaro,Sugawara, Ryozo
, p. 869 - 876 (2007/10/02)
Seven optically active analogues which were (4S)-, (8S)- and (4R)-analogues of the aggregation pheromone of the red flour beetle, Tribolium castaneum, were stereoselectively synthesized from optically pure (R)-(+)-citronellic acid (100percent e.e.) and/or (S)-(-)-2-methyl-1-butanol (93percent e.e.) to elucidate the structure-activity relationship of the pheromone.The (8S)-configuration was derived from (S)-(-)-2-methyl-1-butanol, and the (4S)- or (4R)-configuration was from (R)-(+)-citronellic acid.
