106623-54-5Relevant articles and documents
Synthesis, transacylation kinetics and computational chemistry of a set of arylacetic acid 1β-O-acyl glucuronides
Stachulski, Andrew V.,Berry, Neil G.,Iddon, Lisa,Iqbal, Mazhar,Meng, Xiaoli,Jayapal, Prabha,Johnson, Caroline H.,Nicholson, Jeremy K.,Lindon, John C.,Harding, John R.,Wilson, Ian D.
experimental part, p. 2525 - 2533 (2009/10/30)
Many widely-used non-steroidal anti-inflammatory agents (NSAIDs), e.g. ibuprofen, are extensively metabolised as their acyl glucuronides (AGs), and the reactivity of these AGs raises important questions regarding drug safety and toxicity. In order to unde