106635-81-8 Usage
Uses
Different sources of media describe the Uses of 106635-81-8 differently. You can refer to the following data:
1. Tafenoquine succinate is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the preven tion and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.
2. Tatenoquine is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.
Biochem/physiol Actions
Tafenoquine is an antimalarial primaquine analog being investigated to treat and prevent Plasmodium vivax infections. It can eliminate both blood and liver stages of Plasmodium vivax. Tafenoquine has also been tested as a therapy for leishmaniasis.
Check Digit Verification of cas no
The CAS Registry Mumber 106635-81-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,6,3 and 5 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 106635-81:
(8*1)+(7*0)+(6*6)+(5*6)+(4*3)+(3*5)+(2*8)+(1*1)=118
118 % 10 = 8
So 106635-81-8 is a valid CAS Registry Number.
InChI:InChI=1/C24H28F3N3O3.C4H4O4/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27;5-3(6)1-2-4(7)8/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
106635-81-8Relevant articles and documents
PROCESS FOR THE PREPARATION OF QUINOLINE DERIVATIVES
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Page/Page column 8, (2010/02/07)
The invention relates to a process for the preparation of certain quinoline derivatives, in particular, 8-[(4-amino-1-methylbutyl)amino]-2,6-dimethoxy-4-methyl-5-(3-trifluoromethylphenoxy)quinoline succinate.
