106648-24-2Relevant articles and documents
Novel method for preparing donepezil
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, (2017/06/19)
The present invention relates to a method for preparing Donepezil, comprising the steps of: (a) making 5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile represented by chemical formula 3 react with a benzylpiperidine compound represented by chemical formula 4 to provide 2-((1-benzylpiperidine-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile represented by chemical formula 2; and (b) subjecting 2-((1-benzylpiperidine-4-yl)methyl)-5,6-dimethoxy-1-oxo-2,3-dihydro-1H-indene-2-carbonitrile represented by chemical formula 2 to decyanation reaction, thereby providing Donepezil represented by chemical formula 1.COPYRIGHT KIPO 2017