106649-02-9Relevant articles and documents
A facile and simple synthesis of novel 2-(substituted)-5-(1-methyl-1H- indazol-3-yl)-oxazole derivatives
Reddy, E. Vishnu Vardhan,Ramanatham,Devanna,Srinivasa Reddy,Rajender
, p. E221-E227 (2013)
Novel 2-(substituted)-5-(1-methyl-1H-indazol-3-yl)-oxazoles (13) were synthesized in moderate yields, from 1-methyl-1H-Indazole 3-carboxylic acid (1), by converting it into a variety of amides (12) and further its heterocyclization. The structures of all the compounds have been elucidated on the basis of IR, 1H-NMR, and HRMS.
Catalytic syntheses of N-heterocyclic ynones and ynediones by in situ activation of carboxylic acids with oxalyl chloride
Boersch, Christina,Merkul, Eugen,Mueller, Thomas J. J.
supporting information; experimental part, p. 10448 - 10452 (2011/12/05)
Breaking the bottleneck: α-Keto carboxylic acids and N-heterocyclic carboxylic acids are activated in situ with oxalyl chloride then catalytically alkynylated to give ynediones and N-heterocyclic ynones efficiently in a one-pot fashion. 5-Acylpyrazoles and 2-phenylaminopyrimidines, potentially interesting for pharmaceutical applications, are readily synthesized in concise one-pot, three-component syntheses. Copyright
PROCESS FOR HIGHLY PURE CRYSTALLINE GRANISETRON BASE
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Page/Page column 8, (2008/06/13)
The present invention discloses an improved, commercial process for the preparation of high purity (>99.9%) crystalline base of granisetron (1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide), having the formula (1), and its use in the process for the manufacture of pharmaceutically acceptable hydrochloride salt.