106649-02-9

Basic information

• Product Name: 1-METHYL-1H-INDAZOLE-3-CARBOXY CHLORIDE
• Synonyms: 1-Methyl-3(1H)-indazoloyl chloride;1-Methyl-1H-indazol-3-carbonyl chloride;1-Methylindazole-3-carbonyl chloride;1-Methylindazole-3-carboxylic acid chloride;1-METHYL-1H-INDAZOLE-3-CARBONYL CHLORIDE;1-METHYL-1H-INDAZOLE-3-CARBOXY CHLORIDE
• CAS NO: 106649-02-9
• Molecular Formula: C₉H₇ClN₂O
• Molecular Weight: 194.62
• Mol File: 106649-02-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 126 °C
• Boiling Point: 318.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: -1.86±0.50(Predicted)
• CAS DataBase Reference: 1-METHYL-1H-INDAZOLE-3-CARBOXY CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-INDAZOLE-3-CARBOXY CHLORIDE(106649-02-9)
• EPA Substance Registry System: 1-METHYL-1H-INDAZOLE-3-CARBOXY CHLORIDE(106649-02-9)

Safety Data

• Hazard Codes: Xn
• Statements: 14-34-22
• Safety Statements: 26-36/37/39
• RIDADR: 3261
• Hazardous Substances Data: 106649-02-9(Hazardous Substances Data)

Usage

General Description

1-METHYL-1H-INDAZOLE-3-CARBOXY CHLORIDE is a chemical compound with the molecular formula C9H8ClN2O, primarily used in the synthesis of pharmaceuticals and agrochemicals. It is a chlorinated derivative of 1-methyl-1H-indazole-3-carboxy, commonly used as an intermediate in organic synthesis. 1-METHYL-1H-INDAZOLE-3-CARBOXY CHLORIDE plays a vital role in the production of various drugs as it serves as a precursor in the formation of more complex and biologically active molecules. Its versatile properties and crucial role in the pharmaceutical industry make it a valuable chemical compound for various research and industrial applications.

Upstream product

• 109216-60-6 1-Methyl-1H-indazole-3-carboxylic acid methyl ester 
• 50890-83-0 1-methyl-1H-indazole-3-carboxylic acid 

Downstream Products

• 109889-09-0 granisetron 
• 109216-58-2 LY 278584 
• 124998-65-8 granisetron 
• 107007-99-8 granisetron hydrochloride 
• 121061-98-1 granisetron 
• 1404164-68-6 N-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1-methyl-1H-indazole-3-carboxamide 
• 1404057-87-9 1-methyl-N-[[1-(4-phenylbutyl)-4-piperidinyl]methyl]-1H-indazole-3-carboxamide 

Relevant articles and documents

A facile and simple synthesis of novel 2-(substituted)-5-(1-methyl-1H- indazol-3-yl)-oxazole derivatives

Novel 2-(substituted)-5-(1-methyl-1H-indazol-3-yl)-oxazoles (13) were synthesized in moderate yields, from 1-methyl-1H-Indazole 3-carboxylic acid (1), by converting it into a variety of amides (12) and further its heterocyclization. The structures of all the compounds have been elucidated on the basis of IR, 1H-NMR, and HRMS.

Catalytic syntheses of N-heterocyclic ynones and ynediones by in situ activation of carboxylic acids with oxalyl chloride

Breaking the bottleneck: α-Keto carboxylic acids and N-heterocyclic carboxylic acids are activated in situ with oxalyl chloride then catalytically alkynylated to give ynediones and N-heterocyclic ynones efficiently in a one-pot fashion. 5-Acylpyrazoles and 2-phenylaminopyrimidines, potentially interesting for pharmaceutical applications, are readily synthesized in concise one-pot, three-component syntheses. Copyright

PROCESS FOR HIGHLY PURE CRYSTALLINE GRANISETRON BASE

The present invention discloses an improved, commercial process for the preparation of high purity (>99.9%) crystalline base of granisetron (1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide), having the formula (1), and its use in the process for the manufacture of pharmaceutically acceptable hydrochloride salt.