106670-55-7

Upstream product

• 106670-54-6 4-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-(4-fluoro-phenyl)-2-pyridin-2-yl-butyronitrile 
• 459-22-3 4-fluorophenylacetonitrile 
• 109-09-1 2-chloropyridine 
• 5005-42-5 2-(4-fluorophenyl)-2-(pyridin-2-yl)acetonitrile 

Downstream Products

• 121597-50-0 [3-(4-Fluoro-phenyl)-3-pyridin-2-yl-propyl]-thiourea 
• 121597-43-1 N'-Benzoyl-N-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-N''-[3-(1H-imidazol-4-yl)-propyl]-N-methyl-guanidine 
• 121597-92-0 3-(4-fluorophenyl)-3-pyridin-2-yl-N-methyl-1-propanamine 
• 114667-26-4 1-Benzoyl-3-[3-(4-fluoro-phenyl)-3-pyridin-2-yl-propyl]-thiourea 
• 390-60-3 3-(4-fluorophenyl)-3-pyridin-2-yl-N,N-dimethyl-1-propanamine 

Relevant academic research and scientific papers

IMIDAZOLYL ALKYL GUANIDINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS

New imidazolylalkyl-guanidine derivatives are described, which by virtue of their agonistic action on histamine-H 2 receptors and in part also due to their additional H 1-antagonistic receptor activity can be used in the treatment of cardiac diseases, certain forms of hypertension and diseases of arterial occlusion.These imidazolylalkyl-guanidine derivatives correspond to the general formula I: STR1

Synthesis of Primary ω-Phenyl-ω-pyridylalkylamines

Phthalimidoalkylation of phenylpyridylacetonitriles followed by acidic or basic hydrolysis and decarboxylation is a convenient method for the preparation of pheniramine-like primary amines.Substituted dihydropyrrolamines were isolated as intermediates in the synthesis of the corresponding propylamines.Alternatively, 3,3-diarylpropylamines were prepared via Horner-Emmons reaction of pertinent ketones with diethyl cyanomethanephosphonate followed by reduction with complex hydrides.