1067073-74-8

Basic information

• Product Name: 2-bromo-4,6-dichloro-3-methoxy-5-methylphenol
• Synonyms: 2-bromo-4,6-dichloro-3-methoxy-5-methylphenol
• CAS NO: 1067073-74-8
• Molecular Weight: 285.952
• Mol File: 1067073-74-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-bromo-4,6-dichloro-3-methoxy-5-methylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-4,6-dichloro-3-methoxy-5-methylphenol(1067073-74-8)
• EPA Substance Registry System: 2-bromo-4,6-dichloro-3-methoxy-5-methylphenol(1067073-74-8)

Safety Data

• Hazardous Substances Data: 1067073-74-8(Hazardous Substances Data)

Upstream product

• 1067073-73-7 1-bromo-3,5-dichloro-2,6-dimethoxy-4-methylbenzene 

Relevant articles and documents

Microwave-assisted cleavage of aryl methyl ethers with lithium thioethoxide (LiSEt)

Lithium thioethoxide (LiSEt), a white solid easily prepared from EtSH and n-BuLi in hexane, was identified as a highly efficient reagent for the cleavage (O-demethylation) of aryl methyl ethers, i.e. methyl-protected phenols. Of particular synthetic value are applications in the double deprotection of 1,2-dimethoxyarenes (to give catechols) and in the selective monodeprotection of di- and trimethoxyarenes. The thermal reactions, which are usually performed in DMF as a solvent, can be greatly accelerated through microwave irradiation. In this case, the monodemethylated products are usually formed in high (80-99%) yield within only 15 minutes.