1067181-77-4Relevant academic research and scientific papers
Pyrrolinone derivatives as a new class of P2X3 receptor antagonists. Part 3: Structure-activity relationships of pyrropyrazolone derivatives
Tobinaga, Hiroyuki,Kameyama, Takayuki,Asahi, Kentarou,Horiguchi, Tohru,Oohara, Miho,Taoda, Yoshiyuki,Hata, Kayoko,Hasegawa, Tsuyoshi,Tada, Yukio,Kurihara, Naoko,Kanda, Yasuhiko,Yagi, Shigenori,Tomari, Maki,Tanaka, Yoshikazu,Takahashi, Fumiyo,Taniguchi, Emiko,Takahara, Yukio,Shimada, Shinji,Takeyama, Chie,Yamamoto, Shoichi,Shinohara, Shunji,Kai, Hiroyuki
, (2020/10/30)
The P2X3 receptor is an attractive target for the treatment of pain and chronic coughing, and thus P2X3 antagonists have been developed as new therapeutic drugs. We previously reported selective P2X3 receptor antagonists by derivatization of hit compound 1. As a result, we identified hit compound 3, the structure of which was similar to hit compound 1. On the basis of SAR studies of hit compound 1, we modified hit compound 3 and compound 42 was identified as having analgesic efficacy by oral administration.
NOVEL PYRROLINONE DERIVATIVE AND MEDICINAL COMPOSITION CONTAINING THE SAME
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Page/Page column 80, (2010/01/29)
The present invention provides a compound represented by the formula (I): wherein R1, R2, R3, Z1, Z2, Ra, Rb, q, A and n are as defined in the description, a pharmaceutically acceptable salt or solvate thereof. The compound is useful as P2X3and/or P2X2/3
