106720-64-3

Upstream product

• 119128-13-1 methyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate 
• 25985-08-4 2-(4-methoxybenzyl)isothiourea hydrochloride 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 109211-49-6 1,6-dihydro-2-[[(4-methoxyphenyl)methyl]thio]-4-methyl-6-(3-nitrophenyl)-1-(1-oxo-2-phenylethyl)-5-pyrimidinecarboxylic acid, methyl ester 
• 108956-93-0 2-[[(4-methoxyphenyl)methyl]thio]-4-methyl-6-(3-nitrophenyl)-1,5(6H)-pyrimidinedicarboxylic acid, 1-(1-methylethyl) 5-methyl ester 
• 108931-41-5 1,2,3,4-tetrahydro-6-methyl-4-(3-nitrophenyl)-3-(1-oxopropyl)-2-thioxo-5-pyrimidinecarboxylic acid methyl ester 
• 108932-31-6 1,6-Dihydro-2-[[(4-methoxyphenyl)methyl]thio] 4-methyl-6-(3-nitrophenyl)-1-(1-oxopropyl)-5 pyrimidinecarboxylic acid, methyl ester 

Relevant academic research and scientific papers

2-substituted thio or oxy-4-aryl or heterocyclo-5-carboxy-1,4-dihydropyrimidines, composition containing them, and method of using them to reduce blood pressure

1,4-Dihydropyrimidines of the formula STR1 wherein X is sulfur or oxygen and R4 is aryl or heterocyclo and disclosed. These compounds are useful as cardiovacular agents, particularly anti-hypertensive agents, due to their vasodilator activity.

1,2,3,4-tetrahydro-6-substituted-4-aryl-3-substituted-2-thioxo(or oxo)-5-pyrimidinecarboxylic acids and esters and use thereof to lower blood pressure

Cardiovascular activity is exhibited by compounds having the formula STR1 and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur; R1 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl --(CH2)n --Y2/sub