1067228-15-2Relevant academic research and scientific papers
Microwave-assisted silylation-amination of uracil acyclonucleosides to 4-alkylamino-2(1H)-pyrimidinone analogues
Roy, Vincent,Mieczkowski, Adam,Topalis, Dimitri,Berteina-Raboin, Sabine,Deville-Bonne, Dominique,Nolan, Steven P.,Agrofoglio, Luigi A.
experimental part, p. 2127 - 2133 (2009/04/11)
The synthesis of acyclic N4-substituted cytosine nucleoside phosphonates using a microwave-assisted N4-silylation-amina-tion and olefin cross-metathesis as key assembly steps is described. The microwave-assisted silylation-amination is compared to a conventional heating protocol. While yields and purities of the coupling products were comparable under both conditions, microwave.heat-ing allows a significant acceleration of the reaction (from 48 h to 5 h). Thieme Stuttgart.
