1067230-23-2Relevant academic research and scientific papers
HETEROARYL SUBSTITUTED 3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF
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, (2022/02/15)
The present disclosure provides a compound of Formula (I): (I), or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein Rx and X1 are as defined herein, and methods of making and using same.
Discovery of a potent, selective and orally bioavailable 3,9-diazaspiro[5.5]undeca-2-one CCR5 antagonist
Yang, Hanbiao,Lin, Xiao-Fa,Padilla, Fernando,Gabriel, Stephen D.,Heilek, Gabrielle,Ji, Changhua,Sankuratri, Surya,deRosier, Andre,Berry, Pamela,Rotstein, David M.
scheme or table, p. 209 - 213 (2009/05/26)
Replacement of the cyclic carbamate in our previously disclosed 1-oxa-3,9-diazaspiro[5.5]undecan-2-one template led to the discovery of two novel series of 3,9-diazaspiro[5.5]undecane and undeca-2-one CCR5 antagonists. The synthesis, SAR, and antiviral ac
