1067239-50-2

Basic information

• Product Name: C₁₅H₁₉ClN₂O₃
• Synonyms: C₁₅H₁₉ClN₂O₃
• CAS NO: 1067239-50-2
• Molecular Weight: 310.78
• Mol File: 1067239-50-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₉ClN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₉ClN₂O₃(1067239-50-2)
• EPA Substance Registry System: C₁₅H₁₉ClN₂O₃(1067239-50-2)

Safety Data

• Hazardous Substances Data: 1067239-50-2(Hazardous Substances Data)

Upstream product

• 4461-30-7 2-chloroacetylisocyanate 
• 109421-10-5 3-(cyclohexyloxy)benzeneamine 

Relevant articles and documents

Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression

Recently, a subset of N-phenyl-N′-(2-chloroethyl)ureas (CEU) was found abrogating the nuclear translocation of thioredoxin-1 and arresting the cell cycle in G0/G1 phase. Several derivatives were prepared to assess their effect on cell cycle progression and on the intracellular location of Trx-1. Compounds 1-20, 21-40, and 41-60 exhibited GI50 between 1 and 80 μM. Immunocytochemistry analysis showed compounds 4, 6, 8, 10, 11, 23, 24, 26-31, 34, 37, 41, 44, 46-51, 53, 56, and 57 inhibiting the nuclear translocation of Trx-1. Our results suggest that increasing the electrophilic character of these molecules might enhance the antiproliferative activity at the expense of the selectivity toward thioredoxin-1 and the G0/G1 phase arrest.