106727-83-7Relevant articles and documents
Synthesis of conformationally restricted mimetics of γ-turns and incorporation into desmopressin, an analogue of the peptide hormone vasopressin
Brickmann, Kay,Yuan, ZhongQing,Sethson, Ingmar,Somfai, Peter,Kihlberg, Jan
, p. 2241 - 2253 (1999)
Mimetics of tripeptides adopting inverse and classical γ-turn conformations have been designed and synthesized by an enantioselective approach and then incorporated in an analogue of the hormone vasopressin. In the mimetics one of the amide bonds of the γ
AMIDO-SUBSTITUTED IMIDAZOPYRIDAZINES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE AND/OR ANGIOGENESIS DISORDERS
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Paragraph 0550; 0551; 0552; 0557; 0558, (2017/02/28)
The present invention relates to amido-substituted imidazopyridazine compounds of general formula (I): in which A, E, R2, R3, R4 and n are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients.
QUINAZOLINE COMPOUNDS AS SERINE/THREONINE KINASE INHIBITORS
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Paragraph 00230, (2013/03/26)
Compounds having the formula (I) wherein R1, R2, R3 and Ar as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.