106730-56-7

Upstream product

• 4044-98-8 6-bromo-2-phenylimidazo[1,2-a]pyridine 
• 116355-29-4 (Z)-4-Dimethylamino-3-(2-phenyl-imidazo[1,2-a]pyridin-6-yl)-but-3-en-2-one 
• 107-91-5 cyanoacetic acid amide 
• 116355-10-3 1-(2-Phenyl-imidazo[1,2-a]pyridin-6-yl)-propan-2-one 
• 116355-23-8 6-(2-Methyl-2-propenyl)-2-phenylimidazo[1,2-a]pyridine 

Relevant academic research and scientific papers

Imidazo[1,2-a]pyridines. Synthesis and inotropic activity of new 5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinone derivatives

A series of 1,2-dihydro-5-imidazo[1,2-a]pyridinyl-2(1H)-pyridinones was synthesized and evaluated for positive inotropic activity. 1,2-Dihydro-5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-3- pyridinecarbonitrile (11a) hydrochloride monohydrate (E-1020) was found to be a potent and selective inhibitor of phosphodiesterase III and a long-acting, potent, orally active positive inotropic agent. Additional imidazo[1,2-a]pyridin-2-yl (3a), -3-yl (16), -7-yl (20) and -8-yl (24a) compounds were also prepared. Altering the pyridine substitution from the 2-position to the 6-position produced a 2-fold increase in the i.v. cardiotonic potency (ED50) from 52 to 23 μg/kg, while substitution at the 3-, 7- or 8-position reduced potency. In the 2-positional isomers, introduction of halogen groups enhanced the activity and 3-chloro-1,2-dihydro-5-(6-fluoroimidazo[1,2-a]pyridin-2-yl)-6-methyl-2(1H)- pyridinone (3a) was the most potent (i.v. ED50 11 μg/kg) in this seris. E-1020 is presently under development for the treatment of congestive heart failure.

3-cyano-5-(6-imidazo[1,2-a]pyridyl)pyridin-2-ols useful as cardiotonics

5-(6-Imidazo[1,2-a]pyridyl)pyridine derivatives represented by general formula: STR1 wherein X represents hydrogen atom or methyl group; Y represents cyano group, carboxamido group, hydrogen atom, amino group or a halogen atom; Z represents hydrogen atom or a lower alkyl group; W represents hydrogen atom or a lower alkyl group; R1 represents hydrogen atom, a lower alkyl group, phenyl group, a group shown by formula: --CH2 R4 in which R4 is a lower alkoxy group, or a group shown by formula: STR2 in which R5 and R6 are hydrogen atom or a lower alkyl group R2 represents hydrogen atom or a halogen atom; and R3 represents hydrogen atom, a lower alkyl group or a halogen atom; or a tautomer thereof; and pharmacologically acceptable salts thereof are disclosed. The 5-(6-imidazo[1,2-a]pyridyl)pyridine derivatives are effective for treating congestive heart failures.