106739-25-7Relevant academic research and scientific papers
Synthesis of highly functionalized barbituric acids and study of their interactions with p-glycoprotein and Mg2+ - Potential candidates for multi drug resistance modulation
Singh, Palwinder,Kaur, Jatinder,Bhardwaj, Atul
experimental part, p. 1256 - 1262 (2010/05/02)
A number of barbituric acids with appropriate substituent at C-5 position were synthesized and investigated for their interactions with p-gp and Mg2+. Compounds 5, 6, 8-10, 12-14 and 16 increased the basal activity of p-gp by more than 50% at 0
Reactions of 5-benzoyl-/5-carbaldehyde-/5-(3-phenyl-acryloyl)-6-hydroxy-1H- pyrimidin-2,4-diones with amines: Anti-cancer and metal sequestering properties
Singh, Palwinder,Kaur, Jatinder,Paul, Kamaldeep
, p. 291 - 296 (2008/09/20)
Reactions of-5-benzoyl- / 5-carbaldehyde- / 5-(3-phenyl-acryloyl)-6- hydroxy-1H-pyrimidine-2,4-diones and diamines result in the formation of corresponding enamines. Appreciable anti-cancer activities of compounds 2, 5, 6 and 8 at various cell lines of 59
