1067433-56-0Relevant academic research and scientific papers
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides
Vlahov, Iontcho R.,Wang, Yu,Kleindl, Paul J.,Leamon, Christopher P.
scheme or table, p. 4558 - 4561 (2009/04/08)
Efficient syntheses of folate conjugates of tubulysins and their hydrazides 1a-d are described. These water soluble folate receptor (FR) targeted conjugates are derivatives of folic acid and the potent cytotoxic agents: tubulysin A, B, or their respective hydrazides, connected in regioselective manner via a hydrophilic peptide spacer and a reducible disulfide linker.
