106748-23-6

Basic information

• Product Name: 4-IODOTHIOBENZAMIDE
• Synonyms: 4-IODOTHIOBENZAMIDE
• CAS NO: 106748-23-6
• Molecular Formula: C₇H₆INS
• Molecular Weight: 263.09871
• Mol File: 106748-23-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 164～165℃ (dec)
• Appearance: /
• CAS DataBase Reference: 4-IODOTHIOBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-IODOTHIOBENZAMIDE(106748-23-6)
• EPA Substance Registry System: 4-IODOTHIOBENZAMIDE(106748-23-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 106748-23-6(Hazardous Substances Data)

Upstream product

• 619-58-9 4-iodobenzoic acid 
• 3058-39-7 4-iodobenzonitrile 
• 3956-07-8 4-iodobenzamide 

Downstream Products

• 1589081-34-4 4-(chloromethyl)-2-(4-iodophenyl)thiazole 
• 1589081-19-5 4-amino-6-(benzo[d][1,3]dioxol-5-yl)-2-((2-(4-iodophenyl)thiazol-4-yl)methylthio)pyrimidine-5-carbonitrile 
• 1537168-69-6 1-[2-(4-iodophenyl)-4-methylthiazol-5-yl]ethanone 

Relevant articles and documents

Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity

Methicillin-resistant Staphylococcus aureus (MRSA) infections are a significant burden both clinically and economically worldwide. Increasing resistance to current antibiotics requires an urgent investigation into novel classes of antimicrobial agents. This study presents a structure–activity relationship (SAR) rationale for pyrazole linked phenylthiazole analogues as new antibacterial agents. A library of 23 novel pyrazole linked phenylthiazole compounds were synthesised, followed by screening for antimicrobial activity against five bacterial species and two fungi. The most active compound 14b has shown promising antibacterial activity against the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA, ATCC 43300) strain (MIC 4 μg/mL). Furthermore, the active pyrazole linked phenylthiazole compound exhibited a better toxicity profile than standard antibiotics. In summary, these results demonstrate that a pyrazole linked phenylthiazole scaffold has potential as a lead for further investigation to afford novel antibacterial agents.

Agonists for the adenosine A1 receptor with tunable residence time. a case for nonribose 4-amino-6-aryl-5-cyano-2-thiopyrimidines

We report the synthesis and evaluation of previously unreported 4-amino-6-aryl-5-cyano-2-thiopyrimidines as selective human adenosine A 1 receptor (hA1AR) agonists with tunable binding kinetics, this without affecting their nanomolar affinity for the target receptor. They show a very diverse range of kinetic profiles (from 1 min (compound 52) to 1 h (compound 43)), and their structure-affinity relationships (SAR) and structure-kinetics relationships (SKR) were established. When put in perspective with the increasing importance of binding kinetics in drug discovery, these results bring new evidence of the consequences of affinity-only driven selection of drug candidates, that is, the potential elimination of slightly less active compounds that may display preferable binding kinetics.