1067530-19-1 Usage
General Description
5-(Methylsulfonyl)pyridin-3-amine, also known as MSAPA, is a chemical compound with the molecular formula C7H9N3O2S. It is a pyridine derivative with a sulfonyl group and an amino group attached to the 3-position of the pyridine ring. MSAPA has potential applications in the pharmaceutical industry, as it may have therapeutic properties due to its structural characteristics. Its specific uses and potential effects have not been extensively studied or documented, so further research is needed to fully understand its potential benefits and risks. Overall, 5-(Methylsulfonyl)pyridin-3-amine is a chemical compound with potential pharmaceutical applications that warrants further investigation.
Check Digit Verification of cas no
The CAS Registry Mumber 1067530-19-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,6,7,5,3 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1067530-19:
(9*1)+(8*0)+(7*6)+(6*7)+(5*5)+(4*3)+(3*0)+(2*1)+(1*9)=141
141 % 10 = 1
So 1067530-19-1 is a valid CAS Registry Number.
1067530-19-1Relevant articles and documents
Phosphoinositide-3-kinase inhibitors: Evaluation of substituted alcohols as replacements for the piperazine sulfonamide portion of AMG 511
Lanman, Brian A.,Reed, Anthony B.,Cee, Victor J.,Hong, Fang-Tsao,Pettus, Liping H.,Wurz, Ryan P.,Andrews, Kristin L.,Jiang, Jian,McCarter, John D.,Mullady, Erin L.,San Miguel, Tisha,Subramanian, Raju,Wang, Ling,Whittington, Douglas A.,Wu, Tian,Zalameda, Leeanne,Zhang, Nancy,Tasker, Andrew S.,Hughes, Paul E.,Norman, Mark H.
supporting information, p. 5630 - 5634 (2015/01/08)
Replacement of the piperazine sulfonamide portion of the PI3Kα inhibitor AMG 511 (1) with a range of aliphatic alcohols led to the identification of a truncated gem-dimethylbenzylic alcohol analog, 2-(5-(4-amino-6-methyl-1,3,5-triazin-2-yl)-6-((5-fluoro-6-methoxypyridin-3-yl)amino)pyridin-3-yl)propan-2-ol (7). This compound possessed good in vitro efficacy and pharmacokinetic parameters and demonstrated an EC50 of 239 ng/mL in a mouse liver pharmacodynamic model measuring the inhibition of hepatocyte growth factor (HGF)-induced Akt Ser473 phosphorylation in CD1 nude mice 6 h post-oral dosing.
