106754-20-5

Basic information

• Product Name: DAPHNETIN
• Synonyms: 4,8-DihydroxycouMarin
• CAS NO: 106754-20-5
• Molecular Formula: C9H6O4
• Molecular Weight: 178.142
• EINECS: 207-632-8
• Product Categories: Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 106754-20-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: >260 °C(Solv: acetone (67-64-1); water (7732-18-5))
• Boiling Point: 430.4°C at 760 mmHg
• Flash Point: 184.5°C
• Appearance: /
• Density: 1.563g/cm³
• Vapor Pressure: 5.18E-08mmHg at 25°C
• Refractive Index: 1.689
• PKA: 4.50±1.00(Predicted)
• CAS DataBase Reference: DAPHNETIN(CAS DataBase Reference)
• NIST Chemistry Reference: DAPHNETIN(106754-20-5)
• EPA Substance Registry System: DAPHNETIN(106754-20-5)

Safety Data

• Safety Statements: S22:; S24/25:
• Hazardous Substances Data: 106754-20-5(Hazardous Substances Data)

Usage

Description

Daphnetin, also known as 4,8-dihydroxycoumarin, is a naturally occurring coumarin compound found in various plant species, including Daphne genus plants. It possesses a variety of biological activities, including anti-inflammatory, antiplatelet, and vasorelaxant properties. Its chemical structure features two hydroxyl groups at the 4 and 8 positions, which contribute to its pharmacological properties.

Uses

Used in Pharmaceutical Industry:
Daphnetin is used as an intermediate for the synthesis of various hydroxy metabolites of Warfarin (W498500) and Phenprocoumon (P318820), which are anti-coagulant agents. These metabolites play a crucial role in the development of new anti-coagulant drugs, improving the treatment of blood clotting disorders and reducing the risk of stroke and other thrombotic events.
Used in Anti-inflammatory Applications:
Daphnetin exhibits anti-inflammatory properties, making it a potential candidate for the development of anti-inflammatory drugs. Its ability to modulate inflammatory pathways and reduce the production of pro-inflammatory mediators can be beneficial in treating various inflammatory conditions.
Used in Antiplatelet Applications:
Daphnetin has been shown to possess antiplatelet effects, which can be useful in the prevention and treatment of thrombotic disorders. Its ability to inhibit platelet aggregation and adhesion can help reduce the risk of blood clot formation and associated complications.
Used in Vasorelaxant Applications:
Daphnetin's vasorelaxant properties make it a potential candidate for the development of drugs targeting cardiovascular diseases. Its ability to relax blood vessels and improve blood flow can help alleviate symptoms of hypertension and other cardiovascular conditions.

InChI:InChI=1/C9H6O4/c10-6-3-1-5-2-4-7(11)13-9(5)8(6)12/h1-4,10,12H

Related news

DAPHNETIN (cas 106754-20-5) inhibits high glucose-induced extracellular matrix accumulation, oxidative stress and inflammation in human glomerular mesangial cells08/03/2019

Diabetic nephropathy (DN) is one of the most common causes of end-stage renal disease (ESRD). Oxidative stress and inflammation have been documented to play important roles in the pathogenesis of DN. Daphnetin, a natural coumarin compound, possesses antioxidant and anti-inflammatory activities. ...detailed

DAPHNETIN (cas 106754-20-5) prevents methicillin-resistant Staphylococcus aureus infection by inducing autophagic response08/02/2019

The bacterial pneumonia caused by methicillin-resistant Staphylococcus aureus (MRSA) is a potentially fatal disease, featured with extensive infection, inflammation, and airway dysfunction. With the increasing emerging of drug-resistant strains, new therapeutic strategies beyond canonical antibi...detailed

DAPHNETIN (cas 106754-20-5) protects against cisplatin-induced nephrotoxicity by inhibiting inflammatory and oxidative response08/01/2019

Daphnetin, one of the major bioactive components isolated from Daphne odora, has been reported to have anti-inflammatory and anti-oxidative effects. Inflammation and oxidative stress have been known to play critical roles in cisplatin-induced nephrotoxicity. The purpose of this study was to inve...detailed