1067651-27-7

Basic information

• Product Name: N-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluorobenzyloxymethyl)-2-hydroxy-4-methoxy-butyl]-N',N'-dipropyl-isophthalamide
• CAS NO: 1067651-27-7
• Molecular Weight: 738.872
• Mol File: 1067651-27-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluorobenzyloxymethyl)-2-hydroxy-4-methoxy-butyl]-N',N'-dipropyl-isophthalamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluorobenzyloxymethyl)-2-hydroxy-4-methoxy-butyl]-N',N'-dipropyl-isophthalamide(1067651-27-7)
• EPA Substance Registry System: N-[(1S,2S,4R)-4-((S)-1-benzylcarbamoyl-2-methyl-propylcarbamoyl)-1-(3,5-difluorobenzyloxymethyl)-2-hydroxy-4-methoxy-butyl]-N',N'-dipropyl-isophthalamide(1067651-27-7)

Safety Data

• Hazardous Substances Data: 1067651-27-7(Hazardous Substances Data)

Upstream product

• 1067652-45-2 C₂₆H₃₅F₂N₃O₅ 
• 126926-35-0 N,N-Dipropylisophthalamic acid 

Relevant articles and documents

Design and synthesis of potent and selective BACE-1 inhibitor

Highly potent BACE-1 protease inhibitors have been developed from an inhibitors containing a hydroxyethylene (HE) core displaying aryloxymethyl or benzyloxymethyl P1 side chain and a methoxy P1′ side chain. The target molecules were synthesized in good overall yields from chiral carbohydrate starting materials. The inhibitors show high BACE-1 potency and good, selectivity against cathepsin D, where the most potent inhibitor furnishes BACE-1 Ki ? 1 nM and displays > 1000-fold selectivity over cathepsin D.