1067676-45-2Relevant academic research and scientific papers
Entry to heterocycles based on indium-catalyzed Conia-ene reactions: Asymmetric synthesis of (-)-salinosporamide A
Takahashi, Keisuske,Midori, Michiko,Kawano, Kei,Ishihara, Jun,Hatakeyama, Susumi
, p. 6244 - 6246 (2008)
Conica can: The In(OTf)3-catalyzed cyclization of nitrogen- and oxygen-tethered acetylenic malonic esters gives five- to seven-membered heterocycles in moderate to excellent yields (see scheme; Tf = trifluoromethanesulfonyl). The asymmetric synthesis of (-)-salinosporamide A illustrates the synthetic utility of the method. (Chemical Equation Presented).
