106775-99-9Relevant articles and documents
Lipophilic indole mediated chemoselective α-monobromination of 1,3-dicarbonyl compounds
Wong, Jonathan,Ke, Zhihai,Yeung, Ying-Yeung
, (2020)
A mild and efficient mono-selective bromination of 1,3-dicarbonyl compounds has been developed using lipophilic indole catalysts. Inexpensive and commercially available N-bromosuccinimide (NBS) was used as the brominating reagent. The selectivity was further enhanced when using stoichiometric amount of 3-bromoindole species. Mechanistic studies reveal that the indole catalyst has dual functions in the mono-bromination process.
Preparation method of high-purity 3-methylquinoxaline-2-carboxylic acid
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Paragraph 0075-0077, (2018/09/12)
The invention discloses a preparation method of high-purity 3-methylquinoxaline-2-carboxylic acid. The preparation method comprises the following steps: enabling a compound shown as a formula III to react with acetate to obtain a compound shown as a formula II; enabling the compound shown as the formula II to react with o-phenylenediamine under an acidic condition to prepare a compound shows as aformula I; then, preparing the 3-methylquinoxaline-2-carboxylic acid from the compound shown as the formula I. The preparation method has the advantages of short process route, easiness and convenience in operation, mild conditions, readily-available raw materials, and higher yield and purity of the obtained product. As proved by results of qualitative and quantitative analysis performed on the product by the analysis measures of magnetic resonance imaging, high performance liquid chromatography, gas chromatography and the like, the moisture and solvent residue content in the product are extremely low, and a sample has high uniformity and storage stability, and meets the requirement as a standard product. The formulas I, II and III are shown in the description.
