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106778-42-1

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106778-42-1 Usage

General Description

6-Isoquinolinecarbonitrile(9CI) is a chemical compound with the formula C10H6N2. Its molecular weight is 158.16800 and it is not naturally occurring. It falls under the category of organic compounds and is part of heterocyclic compounds which comprise two or more different elements in the rings. It is also known to belong to the class of organic compounds known as n-acyl alpha amino acids and derivatives. Its appearance and physical state are not commonly described in the available literature. Potential applications and usage of this chemical are not widely documented or established.

Check Digit Verification of cas no

The CAS Registry Mumber 106778-42-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,7,7 and 8 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 106778-42:
(8*1)+(7*0)+(6*6)+(5*7)+(4*7)+(3*8)+(2*4)+(1*2)=141
141 % 10 = 1
So 106778-42-1 is a valid CAS Registry Number.
InChI:InChI=1/C10H6N2/c11-6-8-1-2-10-7-12-4-3-9(10)5-8/h1-5,7H

106778-42-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-Cyanoisoquinoline

1.2 Other means of identification

Product number -
Other names Isoquinoline-6-carbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:106778-42-1 SDS

106778-42-1Relevant articles and documents

Discovery of 2-substituted-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxamide as potent and selective protein arginine methyltransferases 5 inhibitors: Design, synthesis and biological evaluation

Shao, Jingwei,Zhu, Kongkai,Du, Daohai,Zhang, Yuanyuan,Tao, Hongrui,Chen, Zhifeng,Jiang, Hualiang,Chen, Kaixian,Luo, Cheng,Duan, Wenhu

, p. 317 - 333 (2019/01/04)

Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a series of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)amide derivatives targeting PRMT5 were designed with structure-based approach and synthesized. Among them, compound 46 showed potent and selective PRMT5 inhibition activity with an IC50 of 8.5 nM, which was approximately equivalent with the phase I clinical trial PRMT5 inhibitor GSK-3326595 (IC50 = 5.5 nM). Compound 46 also displayed pronounced anti-proliferative activity in MV4-11 cells (GI50 = 18 nM) and antitumor activity in MV4-11 mouse xenografts model. This molecule can serve as an excellent tool compound for probing the biological function of PRMT5.

Preparation method of 1-aminoisoquinoline-6-methanol

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Paragraph 0020; 0023, (2017/08/29)

The invention relates to a synthesis method of 1-aminoisoquinoline-6-methanol. The synthesis method comprises the following steps: reacting 6-bromoisoquinoline used as a raw material to form 6-cyanoisoquinoline; adding a sulfuric acid solution to obtain isoquinoline-6-carboxylic acid; further obtaining isoquinoline-6-methyl formate under the action of absolute methanol and thionyl chloride; further adding m-chloroperoxybenzoic acid in batches in dichloromethane, and reacting to obtain a mixture isoquinoline-6-methyl formate oxynitride; adding into phosphorus oxychloride in batches, cooling after the reaction is completed, pouring into cracked ice, and precipitating a solid 1-chloroisoquinoline-6-methyl formate crude product; directly extracting the water phase with ethyl acetate, and performing centrifugal drying to obtain another 1-chloroisoquinoline-6-methyl formate crude product; merging the crude products of two batches, passing through a silica gel column, and eluting to obtain 1-chloroisoquinoline-6-methyl formate; adding into tetrahydrofuran, then cooling to -30 DEG C, and adding lithium aluminum hydride in batches to obtain a 1-(1-chloroisoquinoline-6-yl)methanol product; mixing with p-methoxybenzylamine, and heating to obtain (1-(4-methoxybenzylamino)isoquinoline-6-yl)methanol; and adding into trifluoroacetic acid, and refluxing to obtain the final product 1-aminoisoquinoline-6-methanol. The method is reasonable in route, low in waste, high in yield and easy to operate, and realizes raw material saving.

NOVEL DIHYDROPYRIMIDIN-2(1H)-ONE COMPOUNDS AS S-NITROSOGLUTATHIONE REDUCTASE INHIBITORS

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Page/Page column 157, (2011/04/24)

The present invention is directed to novel dihydropyrimidin-2(1H)-one compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.

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