106780-66-9

Upstream product

• 106861-67-0 3-(tert-Butyl-dimethyl-silanyloxy)-cyclohexa-1,4-dienecarboxylic acid methyl ester 
• 106780-64-7 (1R,6R)-5-(tert-Butyl-dimethyl-silanyloxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid methyl ester 
• 200182-30-5 methyl 2-hydroxy-7-oxabicyclo[4.1.0]hept-3-ene-4-carboxylate 
• 50983-21-6 1,4-Cyclohexadien-1-carbonsaeure-methylester 

Relevant academic research and scientific papers

Achieving Regio- and Enantioselectivity of P450-Catalyzed Oxidative CH Activation of Small Functionalized Molecules by Structure-Guided Directed Evolution

Directed evolution of the monooxygenase P450-BM3 utilizing iterative saturation mutagenesis at and near the binding site enables a high degree of both regio- and enantioselectivity in the oxidative hydroxylation of cyclohexene-1-carboxylic acid methyl est

Total Synthesis of (-)-Chorismic Acid and (-)-Shikimic Acid

A survey of the enantioselective hydrolyses of 5a-h and 6a-c with commercially available lipases and cholesterol esterases is reported.A procedure for the preparative-scale synthesis of enantiomerically pure (+)-4 and (-)-4 by the enantioselective hydrolysis of 6a or 6b with cholesterol esterase from bovine pancreas is described.Enantiomerically pure (-)-3 is prepared from either (+)-4 or (-)-4.A short total synthesis of (-)-chorismic acid (22percent) from (-)-3 and of (-)-shikimic acid (94percent) from (-)-4 is reported.