1067879-71-3Relevant academic research and scientific papers
Ring-enlargement of dimethylaminopropenoyl cyclopropanes: An efficient route to substituted 2,3-dihydrofurans
Zhang, Rui,Liang, Yongjiu,Zhou, Guangyuan,Wang, Kewei,Dong, Dewen
, p. 8089 - 8092 (2008)
(Chemical Equation Presented) A convenient and efficient synthesis of substituted dihydrofurans is developed via ring-enlargement of 1-dimethylaminopropenoyl-1-carbamoyl/benzoyl cyclopropanes catalyzed by ammonium acetate in acetic acid with high regio- and stereoselectivity. Some of the newly synthesized substituted dihydrofurans are subjected to further synthetic transformation in the presence of NaOH (aq) in ethanol to afford the corresponding 5-aryl-2,3-dihydrofuro[3,2-c]pyridin-4(5H)-ones in high yields.
