106788-62-9

Basic information

• Product Name: Thiourea, 9H-fluoren-2-yl-
• Synonyms: (9H-fluoren-2-yl)thiourea;N-(9H-FLUOREN-2-YL)THIOUREA;Thiourea, N-9H-fluoren-2-yl-
• CAS NO: 106788-62-9
• Molecular Formula: C14H12N2S
• Molecular Weight: 240.32
• Mol File: 106788-62-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Thiourea, 9H-fluoren-2-yl-(CAS DataBase Reference)
• NIST Chemistry Reference: Thiourea, 9H-fluoren-2-yl-(106788-62-9)
• EPA Substance Registry System: Thiourea, 9H-fluoren-2-yl-(106788-62-9)

Safety Data

• Hazardous Substances Data: 106788-62-9(Hazardous Substances Data)

Upstream product

• 153-78-6 2-aminofluorene 
• 6160-65-2 1,1'-Thiocarbonyldiimidazole 

Relevant articles and documents

Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors

A series of novel conformationally-restricted thiourea analogs were designed, synthesized, and evaluated for their anti-HCV activity. Herein we report the synthesis, structure-activity relationships (SARs), and pharmacokinetic properties of this new class of thiourea compounds that showed potent inhibitory activities against HCV in the cell-based subgenomic HCV replicon assay. Among compounds tested, the fluorene compound 4b was found to possess the most potent activity (EC50 = 0.3 μM), lower cytotoxicity (CC50 > 50 μM), and significantly better pharmacokinetic properties compared to its corresponding fluorenone compound 4c.