106789-33-7Relevant academic research and scientific papers
Design, synthesis, and biological evaluation of novel T-Type calcium channel antagonists
McCalmont, William F.,Heady, Tiffany N.,Patterson, Jaclyn R.,Lindenmuth, Michael A.,Haverstick, Doris M.,Gray, Lloyd S.,Macdonald, Timothy L.
, p. 3691 - 3695 (2004)
This paper describes the synthesis of several novel T-type calcium channel antagonists that inhibit calcium influx into the cell, which in turn regulates unknown aspects of the cell cycle pathway that are responsible for cellular proliferation. A library of compounds was synthesized anda brief structure activity relationship will be described. From these studies we have identified a compound (1) that displays anti-proliferative activity in the low micromolar range across a variety of cancer cell lines.
