1067892-78-7

Basic information

• Product Name: 6-phenylethynyl-4-pyrrolidin-1-ylpyrimidine-5-carbaldehyde
• Synonyms: 6-phenylethynyl-4-pyrrolidin-1-ylpyrimidine-5-carbaldehyde
• CAS NO: 1067892-78-7
• Molecular Weight: 277.326
• Mol File: 1067892-78-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-phenylethynyl-4-pyrrolidin-1-ylpyrimidine-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 6-phenylethynyl-4-pyrrolidin-1-ylpyrimidine-5-carbaldehyde(1067892-78-7)
• EPA Substance Registry System: 6-phenylethynyl-4-pyrrolidin-1-ylpyrimidine-5-carbaldehyde(1067892-78-7)

Safety Data

• Hazardous Substances Data: 1067892-78-7(Hazardous Substances Data)

Upstream product

• 536-74-3 phenylacetylene 
• 54503-92-3 4-chloro-6-pyrrolidin-1-yl-pyrimidine-5-carbaldehyde 

Downstream Products

• 1067892-95-8 (7Z)-7-benzylidene-5-methoxy-4-pyrrolidin-1-yl-5,7-dihydrofuro[3,4-d]pyrimidine 
• 1067892-97-0 (7Z)-7-benzylidene-5-ethoxy-4-pyrrolidin-1-yl-5,7-dihydrofuro[3,4-d]pyrimidine 
• 1206805-20-0 5-methoxy-4-pyrrolidin-1-yl-7-phenyl-5H-pyrano[4,3-d]pyrimidine 
• 1416952-42-5 dimethyl [(7Z)-5,7-dihydro-7-(phenylmethylene)-4-(1-pyrrolidinyl)furo[3,4-d]pyrimidin-5-yl]phosphate 
• 1104639-05-5 7-phenyl-4-pyrrolidin-1-ylpyrido[4,3-d]pyrimidine 

Relevant articles and documents

Study on the reactions of acetylenic aldehydes with dimethyl phosphite in basic media: Phosphonate-phosphate rearrangement versus 5-exo-dig cyclization reactions

Tandem reactions of various acetylenic aldehydes with dimethyl phosphite in basic media were investigated. It was shown that in the case of a non-activated triple bond of the starting materials, the well-known Pudovik reaction followed by a subsequent phosphonate-phosphate rearrangement took place. On the other hand when the triple bond of the starting materials is activated by electron-withdrawing heterocycles, a smooth and regioselective tandem 5-exo-dig cyclization reactions becomes possible.

The first tandem acetalization/5-exo-dig cyclization of 6-phenylethynylpyrimidine-5-carbaldehydes: Efficient synthesis of 5-alkoxy-(7Z)-7-benzylidene-5,7-dihydrofuro[3,4-d]pyrimidines

The first example of catalyst-free tandem acetalization/ 5-exo-dig cyclization reactions of 6-phenylethynylpyrimidine-5-carbaldehydes is presented. Efficient novel synthesis of 5,7-dihy-drofuro[3,4-d]pyrimidine core is described. Thieme Stuttgart.