1067914-83-3

Usage

Uses

Used in Pharmaceutical Industry:
Tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate is utilized as a building block in the synthesis of various pharmaceuticals. Its unique structure and functional groups enable the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate is also employed in the agrochemical sector as a precursor for the synthesis of agrochemicals. Its stability and reactivity make it suitable for the preparation of compounds with pesticidal or herbicidal properties.
Used in Specialty Chemicals Industry:
Tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate serves as a key intermediate in the production of specialty chemicals. Its versatility allows for the creation of compounds with specific properties tailored for various industrial applications.
Used as a Reagent in Organic Synthesis:
Due to its stability and compatibility with a wide range of reaction conditions, tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate is used as a reagent in the preparation of other organic compounds. It facilitates the synthesis of complex molecules and contributes to the advancement of organic chemistry.

Upstream product

• 1239596-54-3 3,3-difluoropiperidin-4-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1209780-71-1 tert-butyl 3,3-difluoro-4-hydroxy-piperidine-1-carboxylate 
• 1067914-81-1 3,3-difluoro-1-(phenylmethyl)-4,4-piperidinediol 
• 1788044-01-8 3,3-difluoropiperidine-4,4-diol hydrochloride 
• 851314-55-1 ethyl N-[3-(ethyloxy)-2,2-difluoro-3-oxopropyl]-N-(phenylmethyl)-beta-alaninate 
• 1067915-34-7 ethyl 1-benzyl-5,5-difluoro-4-oxopiperidine-3-carboxylate 

Downstream Products

• 1067914-82-2 (±)-tert-butyl 4-(benzylamino)-3,3-difluoropiperidine-1-carboxylate 
• 1820679-70-6 (±)-tert-butyl 4-amino-3,3-difluoropiperidine-1-carboxylate 
• 1373503-54-8 (R)-2-(1-(tert-butoxycarbonyl)-3,3-difluoropiperidin-4-yl)acetic acid 

Relevant academic research and scientific papers

ERBB RECEPTOR INHIBITORS

Disclosed are compounds inhibiting ErbBs (e. g. HER2), pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat diseases associated ErbBs (especially HER2), including cancer.

TREATMENT OF AUTISM SPECTRUM DISORDERS, OBSESSIVE-COMPULSIVE DISORDER AND ANXIETY DISORDERS

Disclosed are methods for treating NMDA receptor-mediated disorders by administering certain NR2B subunit-selective NMDA (N methyl-D aspartate) antagonists. NMDA receptor-mediated disorders include autism spectrum disorders, obsessive-compulsive disorder and anxiety disorders.

3,3-DIFLUORO-PIPERIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of Formula (I): wherein X, Y, Z, R1, R3, R4 and R5 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).

3,3-DIFLUOROPIPERIDINE CARBAMATE HETEROCYCLIC COMPOUNDS AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of Formula (I), wherein R1 and Z are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).

TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS

Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.

IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS

Compounds of Formula (I) in which A, B, R1, R1a, R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by class 3 and class 5 receptor tyrosine kinases. Particular compounds of this invention have also been found to be inhibitors of Pim-1