1067914-83-3

Basic information

• Product Name: tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate
• Synonyms: 1-Boc-3, 3-difluoro-4,4-(...;1-Boc-3, 3-difluoro-4,4-(dihydroxy)piperidine;tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate;TERT-BUTYL 3,3-DIFLUORO-4,4-DIHIDROXYPIPERIDINE-1-CARBOXYLATE;3,3-Difluoro-4,4-dihydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
• CAS NO: 1067914-83-3
• Molecular Formula: C₁₀H₁₇F₂NO₄
• Molecular Weight: 253.2430864
• Mol File: 1067914-83-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 340.8±42.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• Solubility: soluble in Methanol
• PKA: 10.72±0.40(Predicted)
• CAS DataBase Reference: tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate(1067914-83-3)
• EPA Substance Registry System: tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate(1067914-83-3)

Safety Data

• Hazardous Substances Data: 1067914-83-3(Hazardous Substances Data)

Usage

General Description

"Tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate" is a chemical compound with the molecular formula C11H18F2N2O4. It is a piperidine derivative with two fluorine atoms and two hydroxyl groups attached to the piperidine ring. The tert-butyl group is attached to the nitrogen atom, and the carboxylate group is attached to the piperidine ring. tert-butyl 3,3-difluoro-4,4-dihydroxypiperidine-1-carboxylate is commonly used in organic synthesis as a building block for the preparation of various pharmaceuticals, agrochemicals, and specialty chemicals. It is also used as a reagent in the preparation of other organic compounds due to its stability and compatibility with a wide range of reaction conditions.

Upstream product

• 1239596-54-3 3,3-difluoropiperidin-4-ol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1209780-71-1 tert-butyl 3,3-difluoro-4-hydroxy-piperidine-1-carboxylate 
• 1067914-81-1 3,3-difluoro-1-(phenylmethyl)-4,4-piperidinediol 
• 1788044-01-8 3,3-difluoropiperidine-4,4-diol hydrochloride 
• 851314-55-1 ethyl N-[3-(ethyloxy)-2,2-difluoro-3-oxopropyl]-N-(phenylmethyl)-beta-alaninate 
• 1067915-34-7 ethyl 1-benzyl-5,5-difluoro-4-oxopiperidine-3-carboxylate 

Downstream Products

• 1067914-82-2 (±)-tert-butyl 4-(benzylamino)-3,3-difluoropiperidine-1-carboxylate 
• 1209780-71-1 tert-butyl 3,3-difluoro-4-hydroxy-piperidine-1-carboxylate 
• 1820679-70-6 (±)-tert-butyl 4-amino-3,3-difluoropiperidine-1-carboxylate 

Relevant articles and documents

ERBB RECEPTOR INHIBITORS

Disclosed are compounds inhibiting ErbBs (e. g. HER2), pharmaceutically acceptable salts, hydrates, solvates or stereoisomers thereof and pharmaceutical compositions comprising the compounds. The compound and the pharmaceutical composition can effectively treat diseases associated ErbBs (especially HER2), including cancer.

3,3-DIFLUORO-PIPERIDINE DERIVATIVES AS NR2B NMDA RECEPTOR ANTAGONISTS

Disclosed are chemical entities of Formula (I): wherein X, Y, Z, R1, R3, R4 and R5 are defined herein, as NR2B subtype selective receptor antagonists. Also disclosed are pharmaceutical compositions comprising a chemical entity of Formula (I), and methods of treating various diseases and disorders associated with NR2B antagonism, e.g., diseases and disorders of the CNS, such as depression, by administering a chemical entity of Formula (I).

TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS

Compounds of Formula (I), in which A, B, R1, R1a, R2, R3, R4, R5, R6, and R7 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of immune cell-associated diseases and disorders, such as inflammatory and autoimmune diseases.