1067975-40-9

Upstream product

• 6456-74-2 Glycine tert-butyl ester 
• 104-88-1 4-chlorobenzaldehyde 
• 27532-96-3 glycine tert-butyl ester hydrochloride 

Downstream Products

• 882392-05-4 (S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-propionic acid tert-butyl ester 
• 1025922-89-7 (S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-butyric acid tert-butyl ester 
• 1025891-46-6 (E)-(S)-2-{[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-amino}-5-phenyl-pent-4-enoic acid tert-butyl ester 
• 1026227-92-8 C₂₁H₂₄ClNO₂ 
• 1025891-51-3 C₁₆H₂₀ClNO₂ 
• 1025830-09-4 C₂₀H₂₁ClFNO₂ 
• 1027219-92-6 C₁₇H₂₂ClNO₂ 

Relevant academic research and scientific papers

Highly enantioselective monoalkylation of p-chlorobenzaldehyde imine of glycine tert-butyl ester under mild phase-transfer conditions

The selective monoalkylation of glycine tert-butyl ester aldimine Schiff base 3 has been realized in high chemical yield with excellent enantioselectivity under mild liquid-liquid phase-transfer conditions by the use of binaphthyl-derived chiral quaternar

METHOD FOR PRODUCING OPTICALLY ACTIVE 1-AMINO-2-VINYLCYCLOPROPANECARBOXYLIC ACID ESTER

1-Amino-2-vinylcyclopropanecarboxylic acid ester, which is useful as a synthetic intermediate of pharmaceuticals, can be produced by a process of producing 1-amino-2-vinylcyclopropanecarboxylic acid ester represented by formula (4): including a step of hydrolysis of an optically active 1-N-(arylmethylene)amino-2-vinylcyclopropanecarboxylic acid ester represented by formula (3): which is obtained by reacting an N-(arylmethylene)glycine ester represented by formula (1): with a compound represented by formula (2): in the presence of a base and an optically active quaternary ammonium salt.

PROCESS FOR PRODUCTION OF MONO-SUBSTITUTED ALKYLATED COMPOUND USING ALDIMINE OR DERIVATIVE THEREOF

Disclosed is a process for producing an asymmetric mono-substituted alkylated compound of an α-amino acid which is represented by a specific formula by using an aldimine-type Schiff base. In the process, the alkylation of an aldimine-type Schiff base in a medium in the presence of an optically active quaternary ammonium salt phase transfer catalyst and an inorganic base is started, and subsequently the reaction is quenched at any time preceding the completion of the stoichimetrical reaction, thereby yielding a mono-substituted alkylated product having a high optical purity.