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Acethydrazide Manufacturer/High quality/Best price/In stock
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Acethydrazide
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Acethydrazide
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Acethydrazide
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Acetic hydrazide
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USD $ 3.0-3.0 / Kilogram 1 Kilogram 100 Metric Ton/Year GIHI CHEMICALS CO.,LIMITED Contact Supplier
CAS 1068-57-1 Acethydrazide
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1068-57-1 Usage

Description

Hydrazine, anhydrous appears as a colorless, fuming oily liquid with an ammonia-like odor. Flash point 99°F. Explodes during distillation if traces of air are present. Toxic by inhalation and by skin absorption. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.

Chemical Properties

White moist crystals and chunks

Uses

Acetohydrazide is a metabolite of Isoniazid (I821450) an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis.

Uses

Acetic hydrazide is used as an antibiotic for the treatment of mycobacterium tuberculosis. It is also involved in the preparation of sunitinib b reacting with 5-fluoroisatin. Further, it inhibits mycolic acid biosynthesis. It serves as an important intermediate in organic synthesis such as nitric furosemide Long (nifuratrone) in medicine.

Uses

Acethydrazide can be used in the synthesis of (E)-N′-(2-hydroxybenzylidene)acetohydrazide, an ONO pincer ligand.

Definition

ChEBI: A carbohydrazide that is hydrazine in which one of the hydrogens is replaced by an acetyl group.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. Mutation data reported. Exposure can cause hemolysis and liver damage. See also PHENYLHYDRAZINE. When heated to decomposition it emits toxic fumes of NOX,.

Purification Methods

Acetic hydrazide crystallises as needles from EtOH. It reduces NH3/AgNO3. [Beilstein 2 H 191, 2 IV 435.]
InChI:InChI=1/C7H5ClF3N/c1-4-2-5(7(9,10)11)3-6(8)12-4/h2-3H,1H3

1068-57-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Alfa Aesar (A10969)  Acetic hydrazide, 96%    1068-57-1 25g 512.0CNY Detail
Alfa Aesar (A10969)  Acetic hydrazide, 96%    1068-57-1 100g 1652.0CNY Detail
Alfa Aesar (A10969)  Acetic hydrazide, 96%    1068-57-1 500g 3467.0CNY Detail
Aldrich (A8309)  Acethydrazide  90% 1068-57-1 A8309-5G 501.93CNY Detail
Aldrich (A8309)  Acethydrazide  90% 1068-57-1 A8309-25G 803.79CNY Detail
Aldrich (A8309)  Acethydrazide  90% 1068-57-1 A8309-100G 1,800.63CNY Detail

1068-57-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name acetohydrazide

1.2 Other means of identification

Product number -
Other names Acetic acid hydrazide Acetylhydrazine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1068-57-1 SDS

1068-57-1Synthetic route

acetic anhydride
108-24-7

acetic anhydride

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With pyridine; aluminum oxide; hydrazine at 102 - 104℃; for 1h; microwave irradiation;100%
ethyl acetate
141-78-6

ethyl acetate

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate at 85℃; for 0.00277778h;99%
With hydrazine hydrate98%
With hydrazine hydrate In ethanol; ethyl acetate for 4h; Reflux;98%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate at 40 - 75℃; for 4h; Temperature; Green chemistry; Large scale;98%
With hydrazine hydrate In ethanol Heating;
With hydrazine hydrate Reflux;
acetamido azide

acetamido azide

2,2'-ethane-1,2-diylbissulfanyl-bis-ethanol
5244-34-8

2,2'-ethane-1,2-diylbissulfanyl-bis-ethanol

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With hydrogen In ethanol98%
With hydrogen In ethanol98%
acetic acid
64-19-7

acetic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate for 0.0222222h; Microwave irradiation;86%
With hydrazine hydrate Microwave irradiation;
Stage #1: acetic acid With sulfuric acid In methanol at 20℃; for 4h; Reflux;
Stage #2: With hydrazine hydrate In methanol at 75℃; for 0.5h;
N-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-acetamide
16067-88-2

N-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-acetamide

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With water; hydrazine In ethanol for 0.25h; Ambient temperature;75%
ethyl 2-acetylacetoacetate
603-69-0

ethyl 2-acetylacetoacetate

A

3,5-Dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester
35691-93-1

3,5-Dimethyl-1H-pyrazole-4-carboxylic acid ethyl ester

B

ethyl acetoacetate
141-97-9

ethyl acetoacetate

C

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With hydrazine In chloroform-d1 at 20℃;A 32%
B 68 % Spectr.
C 68%
With hydrazine In chloroform-d1 at 20℃;A 32%
B 68%
C 68 % Spectr.
With hydrazine In acetone at -20℃;A 85 % Spectr.
B 15%
C 15%
diethyl acetylphosphonate
919-19-7

diethyl acetylphosphonate

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 12h;55%
With hydrazine In ethanol for 12h; Product distribution; Mechanism; reaction with other subst. hydrazines;55%
ethyl 4-(1-adamantyl)-3-oxo-2-(1-oxoethyl)butanoate
896109-94-7

ethyl 4-(1-adamantyl)-3-oxo-2-(1-oxoethyl)butanoate

A

3-(1-adamantylmethyl)-1H-pyrazol-5-one

3-(1-adamantylmethyl)-1H-pyrazol-5-one

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With hydrazine hydrate In ethanol for 4h; Reflux;A 39%
B n/a
ethyl 4-(1-adamantyl)-3-oxo-2-(1-oxoethyl)butanoate
896109-94-7

ethyl 4-(1-adamantyl)-3-oxo-2-(1-oxoethyl)butanoate

phenylhydrazine
100-63-0

phenylhydrazine

A

4-adamantan-1-yl-3-oxobutyric acid ethyl ester
33566-14-2

4-adamantan-1-yl-3-oxobutyric acid ethyl ester

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

C

3-(1-adamantylmethyl)-1-phenyl-1H-pyrazol-5-one
33566-15-3

3-(1-adamantylmethyl)-1-phenyl-1H-pyrazol-5-one

Conditions
ConditionsYield
at 70℃; for 2h;A n/a
B n/a
C 27%
glycerol
56-81-5

glycerol

A

(1-methyl-piperidin-2-yl)-methanol
20845-34-5

(1-methyl-piperidin-2-yl)-methanol

B

2,4-dimethyl-2-oxazoline-4-methanol
39986-37-3

2,4-dimethyl-2-oxazoline-4-methanol

C

2-(aminooxy)propanoic acid
2786-22-3

2-(aminooxy)propanoic acid

D

3,5-dihydroxycyclohexanamine

3,5-dihydroxycyclohexanamine

E

acetaldehyde
75-07-0

acetaldehyde

F

acetic acid
64-19-7

acetic acid

G

2-isopropyliminopropane
3332-08-9

2-isopropyliminopropane

H

propionic acid
802294-64-0

propionic acid

I

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

J

allyl alcohol
107-18-6

allyl alcohol

K

hydroxy-2-propanone
116-09-6

hydroxy-2-propanone

L

acrolein
107-02-8

acrolein

M

acetaldehyde methylhydrazone
17167-73-6

acetaldehyde methylhydrazone

N

N-methylproline
68078-09-1

N-methylproline

Conditions
ConditionsYield
With alumina-supported iron; ammonia In water at 340℃; Inert atmosphere;A n/a
B n/a
C n/a
D n/a
E 7.8%
F 5%
G n/a
H 6.7%
I n/a
J 11.3%
K n/a
L n/a
M n/a
N n/a
N-acetylacetamide
625-77-4

N-acetylacetamide

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With hydrazine at 25℃;
With hydrazine hydrochloride; sodium acetate
hydrazinium monoacetate
7335-65-1

hydrazinium monoacetate

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
Kochen;
5-amino-2-hydroxymethyl-benzoic acid hydrazide

5-amino-2-hydroxymethyl-benzoic acid hydrazide

acetic anhydride
108-24-7

acetic anhydride

A

6-acetylaminophthalide
21626-90-4

6-acetylaminophthalide

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
beim Kochen;
N-acetyl-N'-(2-hydroxymethyl-benzoyl)-hydrazine

N-acetyl-N'-(2-hydroxymethyl-benzoyl)-hydrazine

acetic anhydride
108-24-7

acetic anhydride

A

2-benzofuran-1(3H)-one
87-41-2

2-benzofuran-1(3H)-one

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

p-Chlorbenzaldehyd-acethydrazon
26090-73-3

p-Chlorbenzaldehyd-acethydrazon

A

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;
Acetic acid N'-[(4-chloro-phenyl)-hydroxy-methyl]-hydrazide

Acetic acid N'-[(4-chloro-phenyl)-hydroxy-methyl]-hydrazide

A

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
In water at 25℃; Equilibrium constant;
1-N-acetyl-2-acetamido-2-deoxy-β-D-glucopyranosylamine
6205-72-7

1-N-acetyl-2-acetamido-2-deoxy-β-D-glucopyranosylamine

A

3,5-dimethyl-4H-1,2,4-triazol-4-amine
3530-15-2

3,5-dimethyl-4H-1,2,4-triazol-4-amine

B

1-N-acetyl-2-amino-2-deoxy-β-D-glucopyranosylamine
18615-50-4

1-N-acetyl-2-amino-2-deoxy-β-D-glucopyranosylamine

C

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

D

2-amino-2-deoxy-D-glucose hydrazone
77045-60-4, 131158-04-8

2-amino-2-deoxy-D-glucose hydrazone

Conditions
ConditionsYield
With hydrazine at 100℃; for 30h; Product distribution; other temp., time and cat.;
2-acetamido-1-N-(L-β-aspartyl)-2-deoxy-β-D-glucopyranosylamine
33643-34-4

2-acetamido-1-N-(L-β-aspartyl)-2-deoxy-β-D-glucopyranosylamine

A

3,5-dimethyl-4H-1,2,4-triazol-4-amine
3530-15-2

3,5-dimethyl-4H-1,2,4-triazol-4-amine

B

aspartic acid dihydrazide
20318-46-1

aspartic acid dihydrazide

C

1-deoxy-D-fructose hydrazone
86427-77-2

1-deoxy-D-fructose hydrazone

D

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

E

2-amino-2-deoxy-D-glucose hydrazone
77045-60-4, 131158-04-8

2-amino-2-deoxy-D-glucose hydrazone

Conditions
ConditionsYield
With hydrazin sulfate; hydrazine at 105℃; for 10h; Product distribution; other temp.and time;
3-acetylpentane-2,4-dione
815-68-9

3-acetylpentane-2,4-dione

A

1-(3,5-dimethyl-1H-pyrazol-4-yl)ethanone
1123-48-4

1-(3,5-dimethyl-1H-pyrazol-4-yl)ethanone

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

C

acetylacetone
123-54-6

acetylacetone

Conditions
ConditionsYield
With hydrazine In acetone at -20℃;A 70 % Spectr.
B 30 % Spectr.
C 30 % Spectr.
With hydrazine In chloroform-d1 at 20℃;A 26 % Spectr.
B 74 % Spectr.
C 74 % Spectr.
2-acetyldibenzoylmethane
19221-93-3

2-acetyldibenzoylmethane

A

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

B

1,3-diphenylpropanedione
120-46-7

1,3-diphenylpropanedione

Conditions
ConditionsYield
With hydrazine In chloroform-d1 at 20℃;A 100 % Spectr.
B 100 % Spectr.
With phenylhydrazine In chloroform-d1 at 20℃;A 100 % Spectr.
B 100 % Spectr.
3-benzoylpentane-2,4-dione
4728-02-3

3-benzoylpentane-2,4-dione

A

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

B

1-phenylbutan-1,3-dione
93-91-4

1-phenylbutan-1,3-dione

Conditions
ConditionsYield
With hydrazine In chloroform-d1 at 20℃;A 100 % Spectr.
B 100 % Spectr.
ethyl 3-oxo-2-benzoylbutanoate
569-37-9

ethyl 3-oxo-2-benzoylbutanoate

A

ethyl 3-oxo-3-phenylpropionate
94-02-0

ethyl 3-oxo-3-phenylpropionate

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Conditions
ConditionsYield
With hydrazine In chloroform-d1 at 20℃;A 100 % Spectr.
B 100 % Spectr.
ethyl 3-oxo-2-benzoylbutanoate
569-37-9

ethyl 3-oxo-2-benzoylbutanoate

A

ethyl 3-oxo-3-phenylpropionate
94-02-0

ethyl 3-oxo-3-phenylpropionate

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

C

ethyl 3-methyl-5-phenyl-1H-pyrazole-4-carboxylate
76923-16-5

ethyl 3-methyl-5-phenyl-1H-pyrazole-4-carboxylate

Conditions
ConditionsYield
With hydrazine In acetone at -20℃;A 42 % Spectr.
B 42 % Spectr.
C 58 % Spectr.
2-acetyldibenzoylmethane
19221-93-3

2-acetyldibenzoylmethane

phenylhydrazine
100-63-0

phenylhydrazine

A

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

B

1,3-diphenylpropanedione
120-46-7

1,3-diphenylpropanedione

Conditions
ConditionsYield
In chloroform-d1 at 20℃;A 100 % Spectr.
B 100 % Spectr.
5-(2-acetoxy)ethylene-1-benzyl-4-nitroimidazole

5-(2-acetoxy)ethylene-1-benzyl-4-nitroimidazole

A

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

B

(3-Benzyl-5-nitro-3H-imidazol-4-yl)-acetaldehyde

(3-Benzyl-5-nitro-3H-imidazol-4-yl)-acetaldehyde

Conditions
ConditionsYield
With hydrazine
Conditions
ConditionsYield
With hydrazine hydrate In water for 6h; Ambient temperature;
Conditions
ConditionsYield
With hydrazine hydrate for 3h; Ambient temperature;
With hydrazine hydrate In water for 6h; Ambient temperature;
1,6-dihydro-4-amino-3-methyl-6-phenyl-1,2,4-triazin-5(4H)-one

1,6-dihydro-4-amino-3-methyl-6-phenyl-1,2,4-triazin-5(4H)-one

A

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

B

α-hydrazinophenylacetic acid
19866-39-8

α-hydrazinophenylacetic acid

Conditions
ConditionsYield
With sulfuric acid at 22℃; Kinetics; Further Variations:; pH-values; Reagents; Hydrolysis;
diethyl ether
60-29-7

diethyl ether

N,N'-diacetylpiperazin-2,5-dione
3027-05-2

N,N'-diacetylpiperazin-2,5-dione

hydrazine
302-01-2

hydrazine

A

Glycine anhydride
106-57-0

Glycine anhydride

B

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

acetone
67-64-1

acetone

acetic acid isopropylidenehydrazide
3742-63-0

acetic acid isopropylidenehydrazide

Conditions
ConditionsYield
In cyclohexane at 55℃; for 16h;100%
In hexane Reflux;93%
In hexane for 4h; Heating;91%
1-p-tolyl-3-phenylacetone
35730-02-0

1-p-tolyl-3-phenylacetone

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Acetic acid [1-benzyl-2-p-tolyl-eth-(E)-ylidene]-hydrazide
190013-93-5

Acetic acid [1-benzyl-2-p-tolyl-eth-(E)-ylidene]-hydrazide

Conditions
ConditionsYield
With acetic acid In methanol Heating;100%
1-(4-bromophenyl)-3-phenyl-2-propanone
65636-25-1

1-(4-bromophenyl)-3-phenyl-2-propanone

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Acetic acid [1-benzyl-2-(4-bromo-phenyl)-eth-(E)-ylidene]-hydrazide
190013-95-7

Acetic acid [1-benzyl-2-(4-bromo-phenyl)-eth-(E)-ylidene]-hydrazide

Conditions
ConditionsYield
With acetic acid In methanol Heating;100%
1-(4-methoxyphenyl)-3-phenylpropan-2-one
29917-69-9

1-(4-methoxyphenyl)-3-phenylpropan-2-one

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Acetic acid [1-benzyl-2-(4-methoxy-phenyl)-eth-(E)-ylidene]-hydrazide
190013-94-6

Acetic acid [1-benzyl-2-(4-methoxy-phenyl)-eth-(E)-ylidene]-hydrazide

Conditions
ConditionsYield
With acetic acid In methanol Heating;100%
4-(trifluoromethyl)phenylacetyl chloride
74426-51-0

4-(trifluoromethyl)phenylacetyl chloride

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

Acetic acid [1-benzyl-2-(4-trifluoromethyl-phenyl)-eth-(E)-ylidene]-hydrazide

Acetic acid [1-benzyl-2-(4-trifluoromethyl-phenyl)-eth-(E)-ylidene]-hydrazide

Conditions
ConditionsYield
With acetic acid In methanol Heating;100%
acetic acid hydrazide
1068-57-1

acetic acid hydrazide

1,3-Diphenylpropanone
102-04-5

1,3-Diphenylpropanone

Acetic acid (1-benzyl-2-phenyl-ethylidene)-hydrazide

Acetic acid (1-benzyl-2-phenyl-ethylidene)-hydrazide

Conditions
ConditionsYield
With acetic acid In methanol Heating;100%
methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate
859154-69-1

methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

tert-butyl {1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]piperidin-4-yl}carbamate
859154-99-7

tert-butyl {1-[4-(4-chlorophenyl)-5-methyl-4H-1,2,4-triazol-3-yl]piperidin-4-yl}carbamate

Conditions
ConditionsYield
Stage #1: methyl 4-[(tert-butoxycarbonyl)amino]-N-(4-chlorophenyl)piperidine-1-carbimidothioate; acetic acid hydrazide With trifluoroacetic acid In tetrahydrofuran; water for 7h; Heating / reflux;
Stage #2: With ammonia In tetrahydrofuran; water
100%
ethyl 2-cyano-4,5-difluorophenylcarbamate
1217301-65-9

ethyl 2-cyano-4,5-difluorophenylcarbamate

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

8,9-difluoro-2-methyl-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one
1217301-66-0

8,9-difluoro-2-methyl-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one

Conditions
ConditionsYield
In 1-methyl-pyrrolidin-2-one for 2h; Reflux;100%
In 1-methyl-pyrrolidin-2-one for 2h; Reflux;
3-Fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}benzoic acid
1177420-61-9

3-Fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}benzoic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

N'-Acetyl-3-fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}benzohydrazide
1177420-62-0

N'-Acetyl-3-fluoro-4-{3-[(1S)-2-methoxy-1-methylethoxy]-5-[5-(1,3-thiazol-2-yl)-1H-pyrrol-2-yl]phenoxy}benzohydrazide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In dichloromethane at 20℃; Inert atmosphere;100%
triethylammonium 3,4-bis(benzyloxy)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate
1443053-94-8

triethylammonium 3,4-bis(benzyloxy)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

ethyl 5-(2-acetylhydrazinecarbonyl)-3,4-bis(benzyloxy)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate
1443054-10-1

ethyl 5-(2-acetylhydrazinecarbonyl)-3,4-bis(benzyloxy)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;100%
triethylammonium 3,4-bis(benzyloxy)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate
1443053-94-8

triethylammonium 3,4-bis(benzyloxy)-5-(ethoxycarbonyl)-1-(4-methoxyphenyl)-1H-pyrrole-2-carboxylate

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

ethyl 5-(2-acetylhydrazinecarbonyl)-3,4-bis(benzyloxy)-1-(4-5 methoxyphenyl)-1H-pyrrole-2-carboxylate

ethyl 5-(2-acetylhydrazinecarbonyl)-3,4-bis(benzyloxy)-1-(4-5 methoxyphenyl)-1H-pyrrole-2-carboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 0 - 20℃; for 0.5h;100%
4-(diphenylamino)benzaldehyde
4181-05-9

4-(diphenylamino)benzaldehyde

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

C21H19N3O
1471986-40-9

C21H19N3O

Conditions
ConditionsYield
With acetic acid In dimethyl sulfoxide at 20℃; for 1h; Inert atmosphere;100%
With trifluoroacetic acid In methanol at 60℃;320 mg
C16H14O2S3
1471985-08-6

C16H14O2S3

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

C18H18N2O2S3
1471986-41-0

C18H18N2O2S3

Conditions
ConditionsYield
With acetic acid In dimethyl sulfoxide at 20℃; for 1h; Inert atmosphere;100%
5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid
1367870-32-3

5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

N'-acetyl-5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carbohydrazide
1414570-72-1

N'-acetyl-5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carbohydrazide

Conditions
ConditionsYield
Stage #1: 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate In dichloromethane at 20℃; for 1h;
Stage #2: acetic acid hydrazide In dichloromethane at 20℃; for 18h;
100%
Stage #1: 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate In dichloromethane at 20℃; for 1h;
Stage #2: acetic acid hydrazide In dichloromethane at 20℃; for 18h;
100%
Stage #1: 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; isobutyl chloroformate In dichloromethane at 20℃; for 1h;
Stage #2: acetic acid hydrazide In dichloromethane at 20℃; for 18h;
119 mg
5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid
1367870-32-3

5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

isobutyl chloroformate
543-27-1

isobutyl chloroformate

N'-acetyl-5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carbohydrazide
1414570-72-1

N'-acetyl-5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carbohydrazide

Conditions
ConditionsYield
Stage #1: 5-amino-4-methyl-1-phenyl-1H-pyrazole-3-carboxylic acid; isobutyl chloroformate With N-ethyl-N,N-diisopropylamine In dichloromethane at 20℃; for 1h;
Stage #2: acetic acid hydrazide In dichloromethane at 20℃; for 18h;
100%
C33H44ClNO5

C33H44ClNO5

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

C35H49N3O6

C35H49N3O6

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 0.5h;100%
1-(6-{[1-(cyclopropylmethyl)-4-ethyl-3-(4-fluorophenyl)-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

1-(6-{[1-(cyclopropylmethyl)-4-ethyl-3-(4-fluorophenyl)-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

N'-acetyl-1-(6-{[1-(cyclopropylmethyl)-4-ethyl-3-(4-fluorophenyl)-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carbohydrazide

N'-acetyl-1-(6-{[1-(cyclopropylmethyl)-4-ethyl-3-(4-fluorophenyl)-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carbohydrazide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;100%
1-(6-{[4-ethyl-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

1-(6-{[4-ethyl-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carboxylic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

N'-acetyl-1-(6-{[4-ethyl-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carbohydrazide

N'-acetyl-1-(6-{[4-ethyl-3-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}pyrimidin-4-yl)-3,5-dimethyl-1H-pyrazole-4-carbohydrazide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃;100%
salicylaldehyde
90-02-8

salicylaldehyde

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

salicylaldehyde acetylhydrazone
5941-05-9

salicylaldehyde acetylhydrazone

Conditions
ConditionsYield
In propan-1-ol for 24h; Heating;99%
In water; dimethyl sulfoxide at 20℃; Solvent;91%
Stage #1: salicylaldehyde; acetic acid hydrazide Schiff Reaction; Heating;
Stage #2: With carbon tetrabromide In dimethylsulfoxide-d6 at 25℃; Catalytic behavior; Kinetics; Reagent/catalyst; Schiff Reaction;
66%
phthalic anhydride
85-44-9

phthalic anhydride

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

1-Acetyl-2-(o-carboxy-benzoyl)-hydrazin
16103-11-0

1-Acetyl-2-(o-carboxy-benzoyl)-hydrazin

Conditions
ConditionsYield
for 2h; Acylation;99%
In tetrahydrofuran at 20℃; for 0.0833333h; Acylation; ring cleavage;
N,N-dimethyl-formamide dimethyl acetal
4637-24-5

N,N-dimethyl-formamide dimethyl acetal

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

N-[(E)-dimethylaminomethylideneamino]acetamide

N-[(E)-dimethylaminomethylideneamino]acetamide

Conditions
ConditionsYield
In dichloromethane for 0.5h; Reflux;99%
In dichloromethane for 0.5h; Heating;
4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzoic acid
1126367-80-3

4-methyl-3-(4-(pyridin-2-ylmethoxy)benzamido)benzoic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

N-(5-(2-acetylhydrazinecarbonyl)-2-methylphenyl)-4-(pyridin-2-ylmethoxy)benzamide
1126367-22-3

N-(5-(2-acetylhydrazinecarbonyl)-2-methylphenyl)-4-(pyridin-2-ylmethoxy)benzamide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide99%
ethyl 4-(3,5-dichlorophenoxy)-3-oxobutanoate
1226145-00-1

ethyl 4-(3,5-dichlorophenoxy)-3-oxobutanoate

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

C12H10Cl2N2O3
1412896-06-0

C12H10Cl2N2O3

Conditions
ConditionsYield
In ethanol at 20℃; for 7h;99%
2-formylbenzene boronic acid
40138-16-7

2-formylbenzene boronic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

C18H16B2N4O3

C18H16B2N4O3

Conditions
ConditionsYield
In ethanol; water at 23℃;99%
2-formylbenzene boronic acid
40138-16-7

2-formylbenzene boronic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

C18H16B2N4O3

C18H16B2N4O3

Conditions
ConditionsYield
In ethanol; water at 23℃;99%
acetic acid methyl ester
79-20-9

acetic acid methyl ester

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

2-methyl-1,3,4-oxadiazol-5(4H)-one
3069-67-8

2-methyl-1,3,4-oxadiazol-5(4H)-one

Conditions
ConditionsYield
With phosgene; sodium hydrogencarbonate at 0℃; Sealed tube; Green chemistry; Large scale;99%
1-sec-butyl-7-[((R)-cyclopropyl(quinolin-3-yl)methyl)amino]-1H-pyrazolo[4,3-d]pyrimidine-5-carboxylic acid

1-sec-butyl-7-[((R)-cyclopropyl(quinolin-3-yl)methyl)amino]-1H-pyrazolo[4,3-d]pyrimidine-5-carboxylic acid

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

1-sec-butyl-7-[((R)-cyclopropyl(quinolin-3-yl)methyl)amino]-1H-pyrazolo[4,3-d]pyrimidine-5-carboxylic acid N'-acetyl-hydrazide

1-sec-butyl-7-[((R)-cyclopropyl(quinolin-3-yl)methyl)amino]-1H-pyrazolo[4,3-d]pyrimidine-5-carboxylic acid N'-acetyl-hydrazide

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; HATU In N,N-dimethyl-formamide at 23℃; for 16h;99%
Boc-Trp-OH
13139-14-5

Boc-Trp-OH

acetic acid hydrazide
1068-57-1

acetic acid hydrazide

tert-butyl (S)-(1-(2-acetylhydrazineyl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamate

tert-butyl (S)-(1-(2-acetylhydrazineyl)-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamate

Conditions
ConditionsYield
Stage #1: Boc-Trp-OH With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: acetic acid hydrazide at 20℃; for 18h;
99%

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The complexing properties of oxalodihydrazide, Acethydrazide (cas 1068-57-1) and formic hydrazide with Cu(II) in aqueous solution07/24/2019

Hydrazides and their solid complexes demonstrate biological and pharmacological activity. The present study determines the hitherto undescribed coordinating properties of three hydrazides (acethydrazide, formic hydrazide and oxalodihydrazide) towards copper(II) in aqueous solutions by means of v...detailed

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