1068089-34-8

Basic information

• Product Name: 1,6:3,4-Bis-[O-(2,3-diMethoxybutane-2,3-diyl)]-2-O-trifluoroMethanesulphonyl-5-O-benzolyl-Myo-inositol
• Synonyms: 1,6:3,4-Bis-[O-(2,3-diMethoxybutane-2,3-diyl)]-2-O-trifluoroMethanesulphonyl-5-O-benzolyl-Myo-inositol;1,6-O-[(1R,2R)-1,2-DiMethoxy-1,2-diMethyl-1,2-ethanediyl]-3,4-O-[(1S,2S)-1,2-diMethoxy-1,2-diMethyl-1,2-ethanediyl]-Myo-inositol 5-Benzoate 2-(1,1,1-Trifluoro- Methanesulfonate)
• CAS NO: 1068089-34-8
• Molecular Formula: C₂₆H₃₅F₃O₁₃S
• Molecular Weight: 644.6085096
• Product Categories: Carbohydrates & Derivatives;Inositols;Intermediates & Fine Chemicals;Pharmaceuticals;Carbohydrates & Derivatives, Inositols, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 1068089-34-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: >150°C (dec.)
• Appearance: /
• Storage Temp.: Hygroscopic, -20?C Freezer, Under Inert Atmosphere
• Solubility: Chloroform, Methanol
• CAS DataBase Reference: 1,6:3,4-Bis-[O-(2,3-diMethoxybutane-2,3-diyl)]-2-O-trifluoroMethanesulphonyl-5-O-benzolyl-Myo-inositol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6:3,4-Bis-[O-(2,3-diMethoxybutane-2,3-diyl)]-2-O-trifluoroMethanesulphonyl-5-O-benzolyl-Myo-inositol(1068089-34-8)
• EPA Substance Registry System: 1,6:3,4-Bis-[O-(2,3-diMethoxybutane-2,3-diyl)]-2-O-trifluoroMethanesulphonyl-5-O-benzolyl-Myo-inositol(1068089-34-8)

Safety Data

• Hazardous Substances Data: 1068089-34-8(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Uses

One of the scyllo-Inositol derivative ith the amyloid β (Aβ) peptide to inhibit Aβ42 fiber formation.

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 1068088-78-7 5-O-benzoyl-1,6:3,4-bis[O-(2,3-dimethoxybutane-2,3-diyl)]-myo-inositol 

Downstream Products

• 1068089-42-8 2-O-acetyl-5-O-benzoyl-1,6:3,4-bis[O-(2,3-dimethoxybutane-2,3-diyl)]-scyllo-inositol 
• 1194273-15-8 C₂₅H₃₅⁽¹⁸⁾FO₁₀ 

Relevant articles and documents

Synthesis of scyllo-inositol derivatives and their effects on amyloid beta peptide aggregation

scyllo-Inositol has shown promise as a potential therapeutic for Alzheimer's disease, by directly interacting with the amyloid β (Aβ) peptide to inhibit Aβ42 fiber formation. To explore the molecular details of the inositol-Aβ42 interaction, a series of scyllo-inositol derivatives have been synthesized which contain deoxy, fluoro, chloro, and methoxy substitutions. The effects of these compounds on the aggregation cascade of Aβ42 have been investigated using electron microscopy (EM). EM analyses revealed that the 1-deoxy-1-fluoro- and 1,4-dimethyl-scyllo-inositols significantly inhibit the formation of Aβ42 fibers. The other derivatives showed some alterations in the morphology of the Aβ42 fibers produced. These findings indicate the importance of all of the hydroxyl groups of scyllo-inositol for complete inhibition of Aβ aggregation.