106817-52-1 Usage
Description
Felbamate-d4 is intended for use as an internal standard for the quantification of felbamate by GC- or LC-MS. Felbamate is an inhibitor of NMDA receptors and a modulator of GABAA receptors that also has broad-spectrum inhibitory activity against excitatory amino acid receptors. It binds to NMDA channels with dissociation constants of approximately 200, 110, and 55 μM in the resting, activated, and desensitized states, respectively, and inhibits NMDA currents in a use-dependent manner. Felbamate is a positive modulator of α1β2γ2S, α1β3γ2S, α2β2γ2S, and α2β3γ2S subunit-containing GABAA receptors expressed in X. laevis oocytes, with negative modulation of GABAA receptors containing the subunits α1β1, α1β3γ2L, α4β1γ2S, α4β3γ2S, and α6β1γ2S. It inhibits seizures induced by maximal electroshock, pentylenetetrazole , and picrotoxin in mice (ED50s = 16.3, 5.51, and 5.23 mg/kg, respectively). Formulations containing felbamate have been used in the treatment of severe refractory seizures.
Chemical Properties
White Solid
Uses
Different sources of media describe the Uses of 106817-52-1 differently. You can refer to the following data:
1. Antiepileptic, structurally similar to meprobamate
2. Antiepileptic, structurally similar to meprobamate.
Check Digit Verification of cas no
The CAS Registry Mumber 106817-52-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,6,8,1 and 7 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 106817-52:
(8*1)+(7*0)+(6*6)+(5*8)+(4*1)+(3*7)+(2*5)+(1*2)=121
121 % 10 = 1
So 106817-52-1 is a valid CAS Registry Number.
106817-52-1Relevant articles and documents
Felbamate derived compounds
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, (2008/06/13)
The invention relates to the use of certain felbamate derivatives to treat neuropathic pain, obesity, glaucoma, depression, and mood disorders, as well as other conditions.
