106827-69-4

Upstream product

• 76-83-5 trityl chloride 
• 102056-97-3 N-Trityl-L-homoserin-Triethylammonium-Salz 
• 83427-79-6 N-Trityl-L-homoserine 

Downstream Products

• 106827-70-7 Trt-L-Hse(Trt)-OBt 
• 106827-72-9 Trt-L-Hse(Trt)-Gly-NH₂ 
• 106827-71-8 Trt-L-Hse(Trt)-L-Leu-NH₂ 
• 111061-64-4 Trt-L-Hse(Trt)-L-Phe-NH₂ 
• 111061-63-3 Trt-L-Hse(Trt)-L-Met-NH₂ 

Relevant academic research and scientific papers

Synthesis and Chemical Modification of Homoseryl Peptides

The readily synthesised N,O-ditritylhomoserine (4) was used for the efficient incorporation of homoserine (1) into peptides; the derived homoseryl peptides were transformed into peptides of canaline and 1,4-diaminobutyric acid using the Mitsunobu reaction.

Application of the Trt and Fmoc Groups for the Protection of Polyfunctional α-Amino Acids

Simple methods for the preparation of ditrityl amino acids 3 and their application for the synthesis of the peptides 9-27 are described.Selective detritylation of 3 and of the synthesized ditrityl peptides is achieved with 1percent trifluoroacetic acid in dichloromethane.The resulting Nα-detritylated amino acids 5 were converted into the corresponding fluorenylmethoxycarbonyl amino acids 6 under Schotten-Baumann conditions using fluorenylmethyl chloroformate.