106836-76-4Relevant academic research and scientific papers
Chelation-Controlled Grignard Reactions of &α-(1H-1,2,4-Triazol-1-yl) Ketones
Buschmann, Ernst,Zeeh, Bernd,Goetz, Norbert,Sproesser, Linhard,Walker, Nigel
, p. 349 - 355 (2007/10/02)
The high diastereoselectivity of the Grignard addition to α-(1H-1,2,4-triazol-1-yl) ketones (1,4), α-alkoxy-α-(1H-1,2,4-triazol-1-yl) ketones (7,13) and corresponding imidazolyl derivatives can be rationalized via postulated intermediate chelate complexes 3,9.In this case, alkoxy groups as well as azole substituents may function as ligands.For 2d and 8d an X-ray structural analysis was performed.
