1068441-03-1Relevant articles and documents
New NSAIDs-NO hybrid molecules with antiproliferative properties on human prostatic cancer cell lines
Beziere, Nicolas,Goossens, Laurence,Pommery, Jean,Vezin, Herve,Touati, Nadia,Henichart, Jean-Pierre,Pommery, Nicole
scheme or table, p. 4655 - 4657 (2009/04/08)
The design of profen hybrids containing a NO donor moiety connected to an aliphatic spacer led to compounds with a similar cyclooxygenase inhibition compared to their parent profen and with significant antiproliferative activities on PC3 cells. However, inhibition of COX-2 pathway alone did not seem sufficient to inhibit cancer cell proliferation, and NO-release in a time-dependent manner strongly contributes to this activity.
